TY - JOUR
T1 - Bioresorbable vascular scaffold treatment induces the formation of neointimal cap that seals the underlying plaque without compromising the luminal dimensions: a concept based on serial optical coherence tomography data
AU - Bektas, Fatma
AU - Serruys, PWJC (Patrick)
AU - Nakatani, S
AU - Zhang, Y
AU - Farooq, V
AU - Diletti, Roberto
AU - Ligthart, Jurgen
AU - Sheehy, A
AU - van Geuns, Robert Jan
AU - McClean, D
AU - Chevalier, B
AU - Windecker, S
AU - Koolen, J
AU - Ormiston, J
AU - Whitbourn, R
AU - Rapoza, R
AU - Veldhof, S
AU - Onuma, Yoshinobu
AU - Garcia Garcia, Hector
PY - 2015
Y1 - 2015
N2 - Aims: To evaluate the implications of an Absorb bioresorbable vascular scaffold (Absorb BVS) on the morphology of the superficial plaques. Methods and results: Forty-six patients who underwent Absorb BVS implantation and 20 patients implanted with bare metal stents (BMS) who had serial optical coherence tomographic examination at baseline and follow-up were included in this analysis. The thin-capped fibroatheromas (TCFA) were identified in the device implantation regions and in the adjacent native coronary segments. Within all regions, circumferential locations of TCFA and calcific tissues were identified, and the neointimal thickness was measured at follow-up. At six to 12-month follow-up, only 8% of the TCFA detected at baseline were still present in the Absorb BVS and 27% in the BMS implantation segment (p=0.231). Sixty percent of the TCFA in native segments did not change their phenotype at follow-up. At short-term follow-up, significant reduction in the lumen area of the BMS was noted, which was higher compared to that reported in the Absorb BVS group (-2.11 +/- 1.97 mm(2) vs. -1.34 +/- 0.99 mm(2), p=0.026). In Absorb BVS, neointima tissue continued to develop at midterm follow-up (2.17 +/- 0.48 mm(2) vs. 1.38 +/- 0.52 mm(2), p<0.0001) and covered the underlying tissues without compromising the luminal dimensions (5.93 +/- 1.49 mm(2) vs. 6.14 +/- 1.49 mm(2), p=0.571) as it was accommodated by the expanded scaffold (8.28 +/- 1.74 mm(2) vs. 7.67 +/- 1.28 mm(2), p<0.0001). Conclusions: Neointimal tissue develops following either Absorb BVS or BMS implantation and shields lipid tissues. The neointimal response in the BMS causes a higher reduction of luminal dimensions compared to the Absorb BVS. Thus, Absorb BVS may have a value in the invasive re-capping of high-risk plaques.
AB - Aims: To evaluate the implications of an Absorb bioresorbable vascular scaffold (Absorb BVS) on the morphology of the superficial plaques. Methods and results: Forty-six patients who underwent Absorb BVS implantation and 20 patients implanted with bare metal stents (BMS) who had serial optical coherence tomographic examination at baseline and follow-up were included in this analysis. The thin-capped fibroatheromas (TCFA) were identified in the device implantation regions and in the adjacent native coronary segments. Within all regions, circumferential locations of TCFA and calcific tissues were identified, and the neointimal thickness was measured at follow-up. At six to 12-month follow-up, only 8% of the TCFA detected at baseline were still present in the Absorb BVS and 27% in the BMS implantation segment (p=0.231). Sixty percent of the TCFA in native segments did not change their phenotype at follow-up. At short-term follow-up, significant reduction in the lumen area of the BMS was noted, which was higher compared to that reported in the Absorb BVS group (-2.11 +/- 1.97 mm(2) vs. -1.34 +/- 0.99 mm(2), p=0.026). In Absorb BVS, neointima tissue continued to develop at midterm follow-up (2.17 +/- 0.48 mm(2) vs. 1.38 +/- 0.52 mm(2), p<0.0001) and covered the underlying tissues without compromising the luminal dimensions (5.93 +/- 1.49 mm(2) vs. 6.14 +/- 1.49 mm(2), p=0.571) as it was accommodated by the expanded scaffold (8.28 +/- 1.74 mm(2) vs. 7.67 +/- 1.28 mm(2), p<0.0001). Conclusions: Neointimal tissue develops following either Absorb BVS or BMS implantation and shields lipid tissues. The neointimal response in the BMS causes a higher reduction of luminal dimensions compared to the Absorb BVS. Thus, Absorb BVS may have a value in the invasive re-capping of high-risk plaques.
U2 - 10.4244/EIJY14M10_06
DO - 10.4244/EIJY14M10_06
M3 - Article
C2 - 25308301
SN - 1774-024X
VL - 11
SP - 746
EP - 756
JO - EuroIntervention
JF - EuroIntervention
IS - 7
ER -