Biospecimen Reporting for Improved Study Quality

Helen M. Moore, Andrea Kelly, Scott D. Jewell, Lisa M. McShane, Douglas P. Clark, Renata Greenspan, Pierre Hainaut, Daniel F. Hayes, Paula Kim, Elizabeth Mansfield, Olga Potapova, Peter Riegman, Yaffa Rubinstein, Edward Seijo, Stella Somiari, Peter Watson, Heinz Ulrich Weier, Claire Zhu, Jim Vaught*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

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Abstract

Human biospecimens are subject to a number of different collection, processing, and storage factors that can significantly alter their molecular composition and consistency. These biospecimen preanalytical factors, in turn, influence experimental outcomes and the ability to reproduce scientific results. Currently, the extent and type of information specific to the biospecimen preanalytical conditions reported in scientific publications and regulatory submissions varies widely. To improve the quality of research utilizing human tissues, it is critical that information regarding the handling of biospecimens be reported in a thorough, accurate, and standardized manner. The Biospecimen Reporting for Improved Study Quality recommendations outlined herein are intended to apply to any study in which human biospecimens are used. The purpose of reporting these details is to supply others, from researchers to regulators, with more consistent and standardized information to better evaluate, interpret, compare, and reproduce the experimental results. The Biospecimen Reporting for Improved Study Quality guidelines are proposed as an important and timely resource tool to strengthen communication and publications around biospecimen-related research and help reassure patient contributors and the advocacy community that the contributions are valued and respected.
Original languageEnglish
Pages (from-to)57-70
Number of pages14
JournalBiopreservation and Biobanking
Volume9
Issue number1
DOIs
Publication statusPublished - 7 Apr 2011

Bibliographical note

© Mary Ann Liebert, Inc.

Research programs

  • EMC MM-03-24-01

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