Biospecimen Reporting for Improved Study Quality (BRISQ)

Helen M. Moore, Andrea B. Kelly*, Scott D. Jewell, Lisa M. McShane, Douglas P. Clark, Renata Greenspan, Daniel F. Hayes, Pierre Hainaut, Paula Kim, Elizabeth Mansfield, Olga Potapova, Peter Riegman, Yaffa Rubinstein, Edward Seijo, Stella Somiari, Peter Watson, Heinz Ulrich Weier, Claire Zhu, Jim Vaught

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

132 Citations (Scopus)


Human biospecimens are subject to a number of different collection, processing, and storage factors that can significantly alter their molecular composition and consistency. These biospecimen preanalytical factors, in turn, influence experimental outcomes and the ability to reproduce scientific results. Currently, the extent and type of information specific to the biospecimen preanalytical conditions reported in scientific publications and regulatory submissions varies widely. To improve the quality of research utilizing human tissues, it is critical that information regarding the handling of biospecimens be reported in a thorough, accurate, and standardized manner. The Biospecimen Reporting for Improved Study Quality (BRISQ) recommendations outlined herein are intended to apply to any study in which human biospecimens are used. The purpose of reporting these details is to supply others, from researchers to regulators, with more consistent and standardized information to better evaluate, interpret, compare, and reproduce the experimental results. The BRISQ guidelines are proposed as an important and timely resource tool to strengthen communication and publications around biospecimen-related research and help reassure patient contributors and the advocacy community that the contributions are valued and respected.

Original languageEnglish
Pages (from-to)3429-3438
Number of pages10
JournalJournal of Proteome Research
Issue number8
Early online date16 May 2011
Publication statusPublished - 5 Aug 2011

Bibliographical note

Copyright © 2011 American Chemical Society


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