Blood-based 8-hydroxy-2?-deoxyguanosine level: A potential diagnostic biomarker for atrial fibrillation

J Li; D Zhang; KS Ramos; L Baks; M Wiersma; Eva Lanters; Ad Bogers; Natasja de Groot; BJ Brundel

doi:10.1016/j.hrthm.2020.09.017

Blood-based 8-hydroxy-2?-deoxyguanosine level: A potential diagnostic biomarker for atrial fibrillation

J Li, D Zhang, KS Ramos, L Baks, M Wiersma, Eva Lanters, Ad Bogers, Natasja de Groot, BJ Brundel

Research output: Contribution to journal › Article › Academic › peer-review

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Abstract

Background: Recent research findings have revealed a key role of oxidative DNA damage in the pathogenesis of atrial fibrillation (AF). Therefore, the circulating oxidative DNA damage marker 8-hydroxy-2′-deoxyguanosine (8-OHdG) may represent a biomarker for staging AF and identifying patients at risk for AF recurrence and postoperative atrial fibrillation (POAF) after treatment. Objective: The purpose of this study was to investigate whether serum levels of 8-OHdG correlate with the stage of AF, recurrence after AF treatment, and onset of POAF after cardiac surgery. Methods: In this prospective observational study, 8-OHdG levels were detected by enzyme-linked immunosorbent assay in human serum samples. Blood samples were collected from control patients without AF history; patients with paroxysmal AF and persistent AF undergoing electrical cardioversion or pulmonary vein isolation (PVI); and patients with sinus rhythm (SR) undergoing cardiac surgery. AF recurrence was determined during 12-month follow-up. Univariate and multivariate analyses were used to identify changes in 8-OHdG levels between the groups. Results: Compared to the control group, 8-OHdG levels in the patient groups gradually and significantly increased during arrhythmia progression. 8-OHdG levels in AF patients showing AF recurrence after PVI treatment were significantly increased compared to patients without AF recurrence. Moreover, in SR patients undergoing cardiac surgery, 8-OHdG levels were significantly elevated in those showing POAF compared to patients without POAF. Conclusion: 8-OHdG level may represent a potential diagnostic biomarker for AF staging as well as for predicting AF recurrence and POAF after treatment.

Original language	English
Pages (from-to)	271-277
Number of pages	7
Journal	Heart Rhythm
Volume	18
Issue number	2
DOIs	https://doi.org/10.1016/j.hrthm.2020.09.017
Publication status	Published - Feb 2021

Bibliographical note

Funding Information:
Funding sources: This project was funded by the Dutch LSH-Impulse Grant 40-43100-98-008; the Dutch Heart Foundation ( 2013T144 , 2013T096 , 2017T029 and 2020B003 ); CVON-STW2016-14728 AFFIP; and Medical Delta, the Netherlands. Disclosures: The authors have no conflicts of interest to disclose.

Publisher Copyright:
© 2020 Heart Rhythm Society

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@article{6f51a6e14ca541f1aa187f0591ead670,

title = "Blood-based 8-hydroxy-2?-deoxyguanosine level: A potential diagnostic biomarker for atrial fibrillation",

abstract = "Background: Recent research findings have revealed a key role of oxidative DNA damage in the pathogenesis of atrial fibrillation (AF). Therefore, the circulating oxidative DNA damage marker 8-hydroxy-2′-deoxyguanosine (8-OHdG) may represent a biomarker for staging AF and identifying patients at risk for AF recurrence and postoperative atrial fibrillation (POAF) after treatment. Objective: The purpose of this study was to investigate whether serum levels of 8-OHdG correlate with the stage of AF, recurrence after AF treatment, and onset of POAF after cardiac surgery. Methods: In this prospective observational study, 8-OHdG levels were detected by enzyme-linked immunosorbent assay in human serum samples. Blood samples were collected from control patients without AF history; patients with paroxysmal AF and persistent AF undergoing electrical cardioversion or pulmonary vein isolation (PVI); and patients with sinus rhythm (SR) undergoing cardiac surgery. AF recurrence was determined during 12-month follow-up. Univariate and multivariate analyses were used to identify changes in 8-OHdG levels between the groups. Results: Compared to the control group, 8-OHdG levels in the patient groups gradually and significantly increased during arrhythmia progression. 8-OHdG levels in AF patients showing AF recurrence after PVI treatment were significantly increased compared to patients without AF recurrence. Moreover, in SR patients undergoing cardiac surgery, 8-OHdG levels were significantly elevated in those showing POAF compared to patients without POAF. Conclusion: 8-OHdG level may represent a potential diagnostic biomarker for AF staging as well as for predicting AF recurrence and POAF after treatment.",

author = "J Li and D Zhang and KS Ramos and L Baks and M Wiersma and Eva Lanters and Ad Bogers and {de Groot}, Natasja and BJ Brundel",

note = "Funding Information: Funding sources: This project was funded by the Dutch LSH-Impulse Grant 40-43100-98-008; the Dutch Heart Foundation ( 2013T144 , 2013T096 , 2017T029 and 2020B003 ); CVON-STW2016-14728 AFFIP; and Medical Delta, the Netherlands. Disclosures: The authors have no conflicts of interest to disclose. Publisher Copyright: {\textcopyright} 2020 Heart Rhythm Society",

year = "2021",

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doi = "10.1016/j.hrthm.2020.09.017",

language = "English",

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AU - Li, J

AU - Zhang, D

AU - Ramos, KS

AU - Baks, L

AU - Wiersma, M

AU - Lanters, Eva

AU - Bogers, Ad

AU - de Groot, Natasja

AU - Brundel, BJ

N1 - Funding Information: Funding sources: This project was funded by the Dutch LSH-Impulse Grant 40-43100-98-008; the Dutch Heart Foundation ( 2013T144 , 2013T096 , 2017T029 and 2020B003 ); CVON-STW2016-14728 AFFIP; and Medical Delta, the Netherlands. Disclosures: The authors have no conflicts of interest to disclose. Publisher Copyright: © 2020 Heart Rhythm Society

PY - 2021/2

Y1 - 2021/2

N2 - Background: Recent research findings have revealed a key role of oxidative DNA damage in the pathogenesis of atrial fibrillation (AF). Therefore, the circulating oxidative DNA damage marker 8-hydroxy-2′-deoxyguanosine (8-OHdG) may represent a biomarker for staging AF and identifying patients at risk for AF recurrence and postoperative atrial fibrillation (POAF) after treatment. Objective: The purpose of this study was to investigate whether serum levels of 8-OHdG correlate with the stage of AF, recurrence after AF treatment, and onset of POAF after cardiac surgery. Methods: In this prospective observational study, 8-OHdG levels were detected by enzyme-linked immunosorbent assay in human serum samples. Blood samples were collected from control patients without AF history; patients with paroxysmal AF and persistent AF undergoing electrical cardioversion or pulmonary vein isolation (PVI); and patients with sinus rhythm (SR) undergoing cardiac surgery. AF recurrence was determined during 12-month follow-up. Univariate and multivariate analyses were used to identify changes in 8-OHdG levels between the groups. Results: Compared to the control group, 8-OHdG levels in the patient groups gradually and significantly increased during arrhythmia progression. 8-OHdG levels in AF patients showing AF recurrence after PVI treatment were significantly increased compared to patients without AF recurrence. Moreover, in SR patients undergoing cardiac surgery, 8-OHdG levels were significantly elevated in those showing POAF compared to patients without POAF. Conclusion: 8-OHdG level may represent a potential diagnostic biomarker for AF staging as well as for predicting AF recurrence and POAF after treatment.

AB - Background: Recent research findings have revealed a key role of oxidative DNA damage in the pathogenesis of atrial fibrillation (AF). Therefore, the circulating oxidative DNA damage marker 8-hydroxy-2′-deoxyguanosine (8-OHdG) may represent a biomarker for staging AF and identifying patients at risk for AF recurrence and postoperative atrial fibrillation (POAF) after treatment. Objective: The purpose of this study was to investigate whether serum levels of 8-OHdG correlate with the stage of AF, recurrence after AF treatment, and onset of POAF after cardiac surgery. Methods: In this prospective observational study, 8-OHdG levels were detected by enzyme-linked immunosorbent assay in human serum samples. Blood samples were collected from control patients without AF history; patients with paroxysmal AF and persistent AF undergoing electrical cardioversion or pulmonary vein isolation (PVI); and patients with sinus rhythm (SR) undergoing cardiac surgery. AF recurrence was determined during 12-month follow-up. Univariate and multivariate analyses were used to identify changes in 8-OHdG levels between the groups. Results: Compared to the control group, 8-OHdG levels in the patient groups gradually and significantly increased during arrhythmia progression. 8-OHdG levels in AF patients showing AF recurrence after PVI treatment were significantly increased compared to patients without AF recurrence. Moreover, in SR patients undergoing cardiac surgery, 8-OHdG levels were significantly elevated in those showing POAF compared to patients without POAF. Conclusion: 8-OHdG level may represent a potential diagnostic biomarker for AF staging as well as for predicting AF recurrence and POAF after treatment.

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DO - 10.1016/j.hrthm.2020.09.017

M3 - Article

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JO - Heart Rhythm

JF - Heart Rhythm

SN - 1547-5271

IS - 2

ER -

Blood-based 8-hydroxy-2?-deoxyguanosine level: A potential diagnostic biomarker for atrial fibrillation

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