Blunted HPA axis response to stress is related to a persistent Dysregulation Profile in youth

L Ayer; Kirstin Greaves-Lord; RR Althoff; James joseph Hudziak; Gwen Dieleman; Frank Verhulst; Jan van der Ende

doi:10.1016/j.biopsycho.2013.04.002

Blunted HPA axis response to stress is related to a persistent Dysregulation Profile in youth

L Ayer, Kirstin Greaves-Lord, RR Althoff, James joseph Hudziak, Gwen Dieleman, Frank Verhulst, Jan van der Ende

Child and Adolescent Psychiatry / Psychology

Research output: Contribution to journal › Article › Academic › peer-review

24 Citations (Scopus)

Abstract

The Child Behavior Checklist Dysregulation Profile (DP) in youth has been shown to be a predictor of psychopathology later in life. We examined the activity of the hypothalamic pituitary adrenal (HPA) axis in youth with remitted, new, persistent, and no DP. Data from 489 youth (47% boys) participating in a Dutch longitudinal general population study were included (Wave 1 mean age = 11.5, Wave 2 = 14.2). Wave 2 diurnal cortisol patterns and levels in response to a laboratory stress paradigm were compared in youth with DP at Wave 1 only, Wave 2 only, both Waves, and neither Wave. Youth with the DP at Wave 2 only or at both time points showed blunted cortisol responses to stress relative to the other two groups. There were no group or sex differences in diurnal cortisol activity. More research is needed to determine how the association between DP symptoms and HPA axis functioning changes over time. (C) 2013 Elsevier B.V. All rights reserved.

Original language	Undefined/Unknown
Pages (from-to)	343-351
Number of pages	9
Journal	Biological Psychology
Volume	93
Issue number	3
DOIs	https://doi.org/10.1016/j.biopsycho.2013.04.002
Publication status	Published - 2013

Research programs

EMC NIHES-04-55-01

Access to Document

10.1016/j.biopsycho.2013.04.002

http://hdl.handle.net/1765/61232

Cite this

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title = "Blunted HPA axis response to stress is related to a persistent Dysregulation Profile in youth",

abstract = "The Child Behavior Checklist Dysregulation Profile (DP) in youth has been shown to be a predictor of psychopathology later in life. We examined the activity of the hypothalamic pituitary adrenal (HPA) axis in youth with remitted, new, persistent, and no DP. Data from 489 youth (47% boys) participating in a Dutch longitudinal general population study were included (Wave 1 mean age = 11.5, Wave 2 = 14.2). Wave 2 diurnal cortisol patterns and levels in response to a laboratory stress paradigm were compared in youth with DP at Wave 1 only, Wave 2 only, both Waves, and neither Wave. Youth with the DP at Wave 2 only or at both time points showed blunted cortisol responses to stress relative to the other two groups. There were no group or sex differences in diurnal cortisol activity. More research is needed to determine how the association between DP symptoms and HPA axis functioning changes over time. (C) 2013 Elsevier B.V. All rights reserved.",

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AU - Ayer, L

AU - Greaves-Lord, Kirstin

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AU - Dieleman, Gwen

AU - Verhulst, Frank

AU - van der Ende, Jan

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AB - The Child Behavior Checklist Dysregulation Profile (DP) in youth has been shown to be a predictor of psychopathology later in life. We examined the activity of the hypothalamic pituitary adrenal (HPA) axis in youth with remitted, new, persistent, and no DP. Data from 489 youth (47% boys) participating in a Dutch longitudinal general population study were included (Wave 1 mean age = 11.5, Wave 2 = 14.2). Wave 2 diurnal cortisol patterns and levels in response to a laboratory stress paradigm were compared in youth with DP at Wave 1 only, Wave 2 only, both Waves, and neither Wave. Youth with the DP at Wave 2 only or at both time points showed blunted cortisol responses to stress relative to the other two groups. There were no group or sex differences in diurnal cortisol activity. More research is needed to determine how the association between DP symptoms and HPA axis functioning changes over time. (C) 2013 Elsevier B.V. All rights reserved.

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