TY - JOUR
T1 - BMI and body fat mass is inversely associated with vitamin D levels in older individuals
AU - Oliai Araghi, Sadaf
AU - Boon - van Dijk, Suzanne
AU - Ham, Annelies
AU - Brouwer-Brolsma, EM
AU - Enneman, Anke
AU - Sohl, E
AU - Swart, KMA
AU - van der Zwaluw, NL
AU - Wijngaarden, JP
AU - Dhonukshe-Rutten, RAM
AU - Schoor, NM
AU - Zillikens, M.C.
AU - Lips, P
AU - de Groot, LCPGM (Lisette)
AU - Uitterlinden, André
AU - van der Velde, Nathalie
PY - 2015
Y1 - 2015
N2 - Objective: To assess the association between obesity (measured by Body Mass Index (BMI) and fat percentage) and serum 25(OH)D levels in older persons. Design: Cross-sectional analysis of data from 'the B-PROOF study' (B-vitamins for the Prevention Of Osteoporotic Fractures). Participants: 2842 participants aged 65 years and older.Measurements: BMI and fat percentage, measured by Dual Energy X-ray, and serum 25(OH) D levels. Results: Mean age was 74 years (6.5 SD), with 50% women. Mean serum 25(OH)D levels were 55.8 nmol/L (25 SD). BMI and total body fat percentage were significant inversely associated with serum 25(OH)D levels after adjustment for confouders (beta-0.93; 95%CI [-1.15; -0.71], p < 0.001 and beta-0.84; 95%CI [-1.04; -0.64], p < 0.001). This association was most prominent in individuals with a BMI in the 'overweight' and 'obesity' range (beta-1.25 and -0.96 respectively) and fat percentage in the last two upper quartiles (beta-1.86 and -1.37 respectively). Conclusion: In this study, higher BMI and higher body fat percentage were significantly associated with lower serum 25(OH)D levels in older persons. This association was particularly present in individuals with overweight, and higher fat percentages, suggesting that these persons are at increased risk of vitamin D insufficiency.
AB - Objective: To assess the association between obesity (measured by Body Mass Index (BMI) and fat percentage) and serum 25(OH)D levels in older persons. Design: Cross-sectional analysis of data from 'the B-PROOF study' (B-vitamins for the Prevention Of Osteoporotic Fractures). Participants: 2842 participants aged 65 years and older.Measurements: BMI and fat percentage, measured by Dual Energy X-ray, and serum 25(OH) D levels. Results: Mean age was 74 years (6.5 SD), with 50% women. Mean serum 25(OH)D levels were 55.8 nmol/L (25 SD). BMI and total body fat percentage were significant inversely associated with serum 25(OH)D levels after adjustment for confouders (beta-0.93; 95%CI [-1.15; -0.71], p < 0.001 and beta-0.84; 95%CI [-1.04; -0.64], p < 0.001). This association was most prominent in individuals with a BMI in the 'overweight' and 'obesity' range (beta-1.25 and -0.96 respectively) and fat percentage in the last two upper quartiles (beta-1.86 and -1.37 respectively). Conclusion: In this study, higher BMI and higher body fat percentage were significantly associated with lower serum 25(OH)D levels in older persons. This association was particularly present in individuals with overweight, and higher fat percentages, suggesting that these persons are at increased risk of vitamin D insufficiency.
U2 - 10.1007/s12603-015-0657-y
DO - 10.1007/s12603-015-0657-y
M3 - Article
C2 - 26624208
SN - 1279-7707
VL - 19
SP - 980
EP - 985
JO - Journal of Nutrition Health & Aging
JF - Journal of Nutrition Health & Aging
IS - 10
ER -
