Body mass index and the prevalence, severity, and risk of coronary artery disease: an international multicentre study of 13 874 patients

TM Labounty, MJ Gomez, S Achenbach, M Al-Mallah, DS Berman, MJ Budoff, F. Cademartiri, TQ Callister, HJ Chang, V Cheng, KM Chinnaiyan, B Chow, R Cury, A Delago, A Dunning, G Feuchtner, M Hadamitzky, J Hausleiter, P Kaufmann, YJ KimJ Leipsic, FY Lin, E Maffei, G Raff, LJ Shaw, TC Villines, JK Min

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Abstract

Obesity is associated with the presence of coronary artery disease (CAD) risk factors and cardiovascular events. We examined the relationship between body mass index (BMI) and the presence, extent, severity, and risk of CAD in patients referred for coronary computed tomographic angiography (CCTA). We evaluated 13 874 patients from a prospective, international, multicentre registry of individuals without known CAD undergoing CCTA. We compared risk factors, CAD findings, and risk of all-cause mortality and non-fatal myocardial infarction (MI) amongst individuals with underweight (18.520.0 kg/m(2)), normal (20.124.9 kg/m(2)), overweight (2529.9 kg/m(2)), and obese (30 kg/m(2)) BMI. The mean follow-up was 2.4 1.2 years with 143 deaths and 193 MIs. Among underweight, normal weight, overweight, Amongst patients with suspected CAD referred for CCTA, individuals with increased BMI have greater prevalence, extent, and severity of CAD that is not fully explained by the presence of traditional risk factors. A higher BMI is independently associated with increased risk of intermediate-term risk of myocardial infarction.
Original languageUndefined/Unknown
Pages (from-to)456-463
Number of pages8
JournalEuropean Heart Journal-Cardiovascular Imaging
Volume14
Issue number5
DOIs
Publication statusPublished - 2013

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