TY - JOUR
T1 - Body mass index and the prevalence, severity, and risk of coronary artery disease: an international multicentre study of 13 874 patients
AU - Labounty, TM
AU - Gomez, MJ
AU - Achenbach, S
AU - Al-Mallah, M
AU - Berman, DS
AU - Budoff, MJ
AU - Cademartiri, F.
AU - Callister, TQ
AU - Chang, HJ
AU - Cheng, V
AU - Chinnaiyan, KM
AU - Chow, B
AU - Cury, R
AU - Delago, A
AU - Dunning, A
AU - Feuchtner, G
AU - Hadamitzky, M
AU - Hausleiter, J
AU - Kaufmann, P
AU - Kim, YJ
AU - Leipsic, J
AU - Lin, FY
AU - Maffei, E
AU - Raff, G
AU - Shaw, LJ
AU - Villines, TC
AU - Min, JK
PY - 2013
Y1 - 2013
N2 - Obesity is associated with the presence of coronary artery disease (CAD) risk factors and cardiovascular events. We examined the relationship between body mass index (BMI) and the presence, extent, severity, and risk of CAD in patients referred for coronary computed tomographic angiography (CCTA). We evaluated 13 874 patients from a prospective, international, multicentre registry of individuals without known CAD undergoing CCTA. We compared risk factors, CAD findings, and risk of all-cause mortality and non-fatal myocardial infarction (MI) amongst individuals with underweight (18.520.0 kg/m(2)), normal (20.124.9 kg/m(2)), overweight (2529.9 kg/m(2)), and obese (30 kg/m(2)) BMI. The mean follow-up was 2.4 1.2 years with 143 deaths and 193 MIs. Among underweight, normal weight, overweight, Amongst patients with suspected CAD referred for CCTA, individuals with increased BMI have greater prevalence, extent, and severity of CAD that is not fully explained by the presence of traditional risk factors. A higher BMI is independently associated with increased risk of intermediate-term risk of myocardial infarction.
AB - Obesity is associated with the presence of coronary artery disease (CAD) risk factors and cardiovascular events. We examined the relationship between body mass index (BMI) and the presence, extent, severity, and risk of CAD in patients referred for coronary computed tomographic angiography (CCTA). We evaluated 13 874 patients from a prospective, international, multicentre registry of individuals without known CAD undergoing CCTA. We compared risk factors, CAD findings, and risk of all-cause mortality and non-fatal myocardial infarction (MI) amongst individuals with underweight (18.520.0 kg/m(2)), normal (20.124.9 kg/m(2)), overweight (2529.9 kg/m(2)), and obese (30 kg/m(2)) BMI. The mean follow-up was 2.4 1.2 years with 143 deaths and 193 MIs. Among underweight, normal weight, overweight, Amongst patients with suspected CAD referred for CCTA, individuals with increased BMI have greater prevalence, extent, and severity of CAD that is not fully explained by the presence of traditional risk factors. A higher BMI is independently associated with increased risk of intermediate-term risk of myocardial infarction.
U2 - 10.1093/ehjci/jes179
DO - 10.1093/ehjci/jes179
M3 - Article
C2 - 22922955
SN - 2047-2404
VL - 14
SP - 456
EP - 463
JO - European Heart Journal-Cardiovascular Imaging
JF - European Heart Journal-Cardiovascular Imaging
IS - 5
ER -