Bone Phenotyping Approaches in Human, Mice and Zebrafish – Expert Overview of the EU Cost Action GEMSTONE (“GEnomics of MusculoSkeletal traits TranslatiOnal NEtwork”)

Ines Foessl; J. H.Duncan Bassett; Åshild Bjørnerem; Björn Busse; Ângelo Calado; Pascale Chavassieux; Maria Christou; Eleni Douni; Imke A.K. Fiedler; João Eurico Fonseca; Eva Hassler; Wolfgang Högler; Erika Kague; David Karasik; Patricia Khashayar; Bente L. Langdahl; Victoria D. Leitch; Philippe Lopes; Georgios Markozannes; Fiona E.A. McGuigan; Carolina Medina-Gomez; Evangelia Ntzani; Ling Oei; Claes Ohlsson; Pawel Szulc; Jonathan H. Tobias; Katerina Trajanoska; Şansın Tuzun; Amina Valjevac; Bert van Rietbergen; Graham R. Williams; Tatjana Zekic; Fernando Rivadeneira; Barbara Obermayer-Pietsch

doi:10.3389/fendo.2021.720728

Bone Phenotyping Approaches in Human, Mice and Zebrafish – Expert Overview of the EU Cost Action GEMSTONE (“GEnomics of MusculoSkeletal traits TranslatiOnal NEtwork”)

Ines Foessl
, J. H.Duncan Bassett
, Åshild Bjørnerem
, Björn Busse
, Ângelo Calado
, Pascale Chavassieux
, Maria Christou
, Eleni Douni
, Imke A.K. Fiedler
, João Eurico Fonseca
, Eva Hassler
, Wolfgang Högler
, Erika Kague
, David Karasik
, Patricia Khashayar
, Bente L. Langdahl
, Victoria D. Leitch
, Philippe Lopes
, Georgios Markozannes
, Fiona E.A. McGuigan

Carolina Medina-Gomez, Evangelia Ntzani, Ling Oei, Claes Ohlsson, Pawel Szulc, Jonathan H. Tobias, Katerina Trajanoska, Şansın Tuzun, Amina Valjevac, Bert van Rietbergen, Graham R. Williams, Tatjana Zekic, Fernando Rivadeneira, Barbara Obermayer-Pietsch^*

^*Corresponding author for this work

Internal Medicine

Imperial College London
University of Tromsø – The Arctic University of Norway
Oslo University Hospital
University Medical Center Hamburg-Eppendorf
Faculdade de Medicina da Universidade de Lisboa
Université de Lyon
University of Ioannina Medical School
Biomedical Sciences Research Center Al. Fleming
Agricultural University of Athens
Centro Hospitalar Universitário Lisboa Norte
Medical University of Graz
Johannes Kepler University Linz
University of Bristol
Bar-Ilan University
Ghent University
Aarhus University Hospital
Royal Melbourne Institute of Technology University
Lund University (Malmö)
Brown University
The Sahlgrenska Academy at the University of Gothenburg
Sahlgrenska University Hospital
Bristol Medical School
Istanbul University - Cerrahpaşa
University of Sarajevo
Eindhoven University of Technology
University Hospital Centre Rijeka

Research output: Contribution to journal › Review article › Academic › peer-review

23 Citations (Scopus)

34 Downloads (Pure)

Abstract

A synoptic overview of scientific methods applied in bone and associated research fields across species has yet to be published. Experts from the EU Cost Action GEMSTONE (“GEnomics of MusculoSkeletal Traits translational Network”) Working Group 2 present an overview of the routine techniques as well as clinical and research approaches employed to characterize bone phenotypes in humans and selected animal models (mice and zebrafish) of health and disease. The goal is consolidation of knowledge and a map for future research. This expert paper provides a comprehensive overview of state-of-the-art technologies to investigate bone properties in humans and animals – including their strengths and weaknesses. New research methodologies are outlined and future strategies are discussed to combine phenotypic with rapidly developing –omics data in order to advance musculoskeletal research and move towards “personalised medicine”.

Original language	English
Article number	720728
Journal	Frontiers in Endocrinology
Volume	12
DOIs	https://doi.org/10.3389/fendo.2021.720728
Publication status	Published - 1 Dec 2021

Bibliographical note

Funding Information:
Funding was obtained from the GEMSTONE COST Action (CA18139). The Origins of Bone and Cartilage Disease Programme analysed the skeletal phenotypes of knockout mice generated by the International Mouse Phenotyping Consortium (IMPC) and was funded by a Welcome Trust Strategic Award (101123) to GRW and JHDB. IF is enrolled in the PhD program MOLIN at the Medical University of Graz, funded by the Austrian Science Fund (FWF). FM is funded by the Swedish Research Council (2018-02981), Greta and Johan Kock Foundation, the A. Påhlsson, A. Osterlund Foundation and H Järnhardt Foundations, King Gustav V 80 year fund, Swedish Rheumatism foundation, Skåne University Hospital Research Fund, Research and Development Council of Region Skåne.

Publisher Copyright:
Copyright © 2021 Foessl, Bassett, Bjørnerem, Busse, Calado, Chavassieux, Christou, Douni, Fiedler, Fonseca, Hassler, Högler, Kague, Karasik, Khashayar, Langdahl, Leitch, Lopes, Markozannes, McGuigan, Medina-Gomez, Ntzani, Oei, Ohlsson, Szulc, Tobias, Trajanoska, Tuzun, Valjevac, van Rietbergen, Williams, Zekic, Rivadeneira and Obermayer-Pietsch.

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

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10.3389/fendo.2021.720728

fendo-12-720728Licence: CC BY

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Foessl, I., Bassett, J. H. D., Bjørnerem, Å., Busse, B., Calado, Â., Chavassieux, P., Christou, M., Douni, E., Fiedler, I. A. K., Fonseca, J. E., Hassler, E., Högler, W., Kague, E., Karasik, D., Khashayar, P., Langdahl, B. L., Leitch, V. D., Lopes, P., Markozannes, G., ... Obermayer-Pietsch, B. (2021). Bone Phenotyping Approaches in Human, Mice and Zebrafish – Expert Overview of the EU Cost Action GEMSTONE (“GEnomics of MusculoSkeletal traits TranslatiOnal NEtwork”). Frontiers in Endocrinology, 12, Article 720728. https://doi.org/10.3389/fendo.2021.720728

@article{3e1d64979dcc49a3ae6dc2af45e8dc2f,

title = "Bone Phenotyping Approaches in Human, Mice and Zebrafish {\textendash} Expert Overview of the EU Cost Action GEMSTONE ({\textquotedblleft}GEnomics of MusculoSkeletal traits TranslatiOnal NEtwork{\textquotedblright})",

abstract = "A synoptic overview of scientific methods applied in bone and associated research fields across species has yet to be published. Experts from the EU Cost Action GEMSTONE ({\textquotedblleft}GEnomics of MusculoSkeletal Traits translational Network{\textquotedblright}) Working Group 2 present an overview of the routine techniques as well as clinical and research approaches employed to characterize bone phenotypes in humans and selected animal models (mice and zebrafish) of health and disease. The goal is consolidation of knowledge and a map for future research. This expert paper provides a comprehensive overview of state-of-the-art technologies to investigate bone properties in humans and animals {\textendash} including their strengths and weaknesses. New research methodologies are outlined and future strategies are discussed to combine phenotypic with rapidly developing {\textendash}omics data in order to advance musculoskeletal research and move towards {\textquotedblleft}personalised medicine{\textquotedblright}.",

author = "Ines Foessl and Bassett, \{J. H.Duncan\} and {\AA}shild Bj{\o}rnerem and Bj{\"o}rn Busse and {\^A}ngelo Calado and Pascale Chavassieux and Maria Christou and Eleni Douni and Fiedler, \{Imke A.K.\} and Fonseca, \{Jo{\~a}o Eurico\} and Eva Hassler and Wolfgang H{\"o}gler and Erika Kague and David Karasik and Patricia Khashayar and Langdahl, \{Bente L.\} and Leitch, \{Victoria D.\} and Philippe Lopes and Georgios Markozannes and McGuigan, \{Fiona E.A.\} and Carolina Medina-Gomez and Evangelia Ntzani and Ling Oei and Claes Ohlsson and Pawel Szulc and Tobias, \{Jonathan H.\} and Katerina Trajanoska and {\c S}ansın Tuzun and Amina Valjevac and \{van Rietbergen\}, Bert and Williams, \{Graham R.\} and Tatjana Zekic and Fernando Rivadeneira and Barbara Obermayer-Pietsch",

note = "Funding Information: Funding was obtained from the GEMSTONE COST Action (CA18139). The Origins of Bone and Cartilage Disease Programme analysed the skeletal phenotypes of knockout mice generated by the International Mouse Phenotyping Consortium (IMPC) and was funded by a Welcome Trust Strategic Award (101123) to GRW and JHDB. IF is enrolled in the PhD program MOLIN at the Medical University of Graz, funded by the Austrian Science Fund (FWF). FM is funded by the Swedish Research Council (2018-02981), Greta and Johan Kock Foundation, the A. P{\aa}hlsson, A. Osterlund Foundation and H J{\"a}rnhardt Foundations, King Gustav V 80 year fund, Swedish Rheumatism foundation, Sk{\aa}ne University Hospital Research Fund, Research and Development Council of Region Sk{\aa}ne. Publisher Copyright: Copyright {\textcopyright} 2021 Foessl, Bassett, Bj{\o}rnerem, Busse, Calado, Chavassieux, Christou, Douni, Fiedler, Fonseca, Hassler, H{\"o}gler, Kague, Karasik, Khashayar, Langdahl, Leitch, Lopes, Markozannes, McGuigan, Medina-Gomez, Ntzani, Oei, Ohlsson, Szulc, Tobias, Trajanoska, Tuzun, Valjevac, van Rietbergen, Williams, Zekic, Rivadeneira and Obermayer-Pietsch.",

year = "2021",

month = dec,

day = "1",

doi = "10.3389/fendo.2021.720728",

language = "English",

volume = "12",

journal = "Frontiers in Endocrinology",

issn = "1664-2392",

publisher = "Frontiers Media SA",

}

Foessl, I, Bassett, JHD, Bjørnerem, Å, Busse, B, Calado, Â, Chavassieux, P, Christou, M, Douni, E, Fiedler, IAK, Fonseca, JE, Hassler, E, Högler, W, Kague, E, Karasik, D, Khashayar, P, Langdahl, BL, Leitch, VD, Lopes, P, Markozannes, G, McGuigan, FEA, Medina-Gomez, C, Ntzani, E, Oei, L, Ohlsson, C, Szulc, P, Tobias, JH, Trajanoska, K, Tuzun, Ş, Valjevac, A, van Rietbergen, B, Williams, GR, Zekic, T, Rivadeneira, F & Obermayer-Pietsch, B 2021, 'Bone Phenotyping Approaches in Human, Mice and Zebrafish – Expert Overview of the EU Cost Action GEMSTONE (“GEnomics of MusculoSkeletal traits TranslatiOnal NEtwork”)', Frontiers in Endocrinology, vol. 12, 720728. https://doi.org/10.3389/fendo.2021.720728

Bone Phenotyping Approaches in Human, Mice and Zebrafish – Expert Overview of the EU Cost Action GEMSTONE (“GEnomics of MusculoSkeletal traits TranslatiOnal NEtwork”). / Foessl, Ines; Bassett, J. H.Duncan; Bjørnerem, Åshild et al.
In: Frontiers in Endocrinology, Vol. 12, 720728, 01.12.2021.

Research output: Contribution to journal › Review article › Academic › peer-review

TY - JOUR

T1 - Bone Phenotyping Approaches in Human, Mice and Zebrafish – Expert Overview of the EU Cost Action GEMSTONE (“GEnomics of MusculoSkeletal traits TranslatiOnal NEtwork”)

AU - Foessl, Ines

AU - Bassett, J. H.Duncan

AU - Bjørnerem, Åshild

AU - Busse, Björn

AU - Calado, Ângelo

AU - Chavassieux, Pascale

AU - Christou, Maria

AU - Douni, Eleni

AU - Fiedler, Imke A.K.

AU - Fonseca, João Eurico

AU - Hassler, Eva

AU - Högler, Wolfgang

AU - Kague, Erika

AU - Karasik, David

AU - Khashayar, Patricia

AU - Langdahl, Bente L.

AU - Leitch, Victoria D.

AU - Lopes, Philippe

AU - Markozannes, Georgios

AU - McGuigan, Fiona E.A.

AU - Medina-Gomez, Carolina

AU - Ntzani, Evangelia

AU - Oei, Ling

AU - Ohlsson, Claes

AU - Szulc, Pawel

AU - Tobias, Jonathan H.

AU - Trajanoska, Katerina

AU - Tuzun, Şansın

AU - Valjevac, Amina

AU - van Rietbergen, Bert

AU - Williams, Graham R.

AU - Zekic, Tatjana

AU - Rivadeneira, Fernando

AU - Obermayer-Pietsch, Barbara

N1 - Funding Information: Funding was obtained from the GEMSTONE COST Action (CA18139). The Origins of Bone and Cartilage Disease Programme analysed the skeletal phenotypes of knockout mice generated by the International Mouse Phenotyping Consortium (IMPC) and was funded by a Welcome Trust Strategic Award (101123) to GRW and JHDB. IF is enrolled in the PhD program MOLIN at the Medical University of Graz, funded by the Austrian Science Fund (FWF). FM is funded by the Swedish Research Council (2018-02981), Greta and Johan Kock Foundation, the A. Påhlsson, A. Osterlund Foundation and H Järnhardt Foundations, King Gustav V 80 year fund, Swedish Rheumatism foundation, Skåne University Hospital Research Fund, Research and Development Council of Region Skåne. Publisher Copyright: Copyright © 2021 Foessl, Bassett, Bjørnerem, Busse, Calado, Chavassieux, Christou, Douni, Fiedler, Fonseca, Hassler, Högler, Kague, Karasik, Khashayar, Langdahl, Leitch, Lopes, Markozannes, McGuigan, Medina-Gomez, Ntzani, Oei, Ohlsson, Szulc, Tobias, Trajanoska, Tuzun, Valjevac, van Rietbergen, Williams, Zekic, Rivadeneira and Obermayer-Pietsch.

PY - 2021/12/1

Y1 - 2021/12/1

N2 - A synoptic overview of scientific methods applied in bone and associated research fields across species has yet to be published. Experts from the EU Cost Action GEMSTONE (“GEnomics of MusculoSkeletal Traits translational Network”) Working Group 2 present an overview of the routine techniques as well as clinical and research approaches employed to characterize bone phenotypes in humans and selected animal models (mice and zebrafish) of health and disease. The goal is consolidation of knowledge and a map for future research. This expert paper provides a comprehensive overview of state-of-the-art technologies to investigate bone properties in humans and animals – including their strengths and weaknesses. New research methodologies are outlined and future strategies are discussed to combine phenotypic with rapidly developing –omics data in order to advance musculoskeletal research and move towards “personalised medicine”.

AB - A synoptic overview of scientific methods applied in bone and associated research fields across species has yet to be published. Experts from the EU Cost Action GEMSTONE (“GEnomics of MusculoSkeletal Traits translational Network”) Working Group 2 present an overview of the routine techniques as well as clinical and research approaches employed to characterize bone phenotypes in humans and selected animal models (mice and zebrafish) of health and disease. The goal is consolidation of knowledge and a map for future research. This expert paper provides a comprehensive overview of state-of-the-art technologies to investigate bone properties in humans and animals – including their strengths and weaknesses. New research methodologies are outlined and future strategies are discussed to combine phenotypic with rapidly developing –omics data in order to advance musculoskeletal research and move towards “personalised medicine”.

UR - https://www.scopus.com/pages/publications/85121349738

U2 - 10.3389/fendo.2021.720728

DO - 10.3389/fendo.2021.720728

M3 - Review article

C2 - 34925226

AN - SCOPUS:85121349738

SN - 1664-2392

VL - 12

JO - Frontiers in Endocrinology

JF - Frontiers in Endocrinology

M1 - 720728

ER -

Bone Phenotyping Approaches in Human, Mice and Zebrafish – Expert Overview of the EU Cost Action GEMSTONE (“GEnomics of MusculoSkeletal traits TranslatiOnal NEtwork”)

Abstract

Bibliographical note

UN SDGs

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