Brain artery diameters and risk of dementia and stroke

Jesus D. Melgarejo; Kursat Gurel; Cassidy Rose Compton; Minghua Liu; Vanessa Guzman; Stephanie Assuras; Bonnie E. Levin; Mitchell S.V. Elkind; M. Kamran Ikram; Maryam Kavousi; M. Arfan Ikram; Clinton Wright; Fabrice Crivello; Alexandre Laurent; Christophe Tzourio; Meike W. Vernooij; Tatjana Rundek; Zhen Yu Zhang; Daniel Bos; Jose Gutierrez

doi:10.1002/alz.13712

Brain artery diameters and risk of dementia and stroke

Jesus D. Melgarejo, Kursat Gurel, Cassidy Rose Compton, Minghua Liu, Vanessa Guzman, Stephanie Assuras, Bonnie E. Levin, Mitchell S.V. Elkind, M. Kamran Ikram, Maryam Kavousi, M. Arfan Ikram, Clinton Wright, Fabrice Crivello, Alexandre Laurent, Christophe Tzourio, Meike W. Vernooij, Tatjana Rundek, Zhen Yu Zhang, Daniel Bos, Jose Gutierrez^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

3 Citations (Scopus)

20 Downloads (Pure)

Abstract

INTRODUCTION:

We tested the association of brain artery diameters with dementia and stroke risk in three distinct population-based studies using conventional T2-weighted brain magnetic resonance imaging (MRI) images.

METHODS:

We included 8420 adults > 40 years old from three longitudinal population-based studies with brain MRI scans. We estimated and meta-analyzed the hazard ratios (HRs) of the brain and carotids and basilar diameters associated with dementia and stroke.

RESULT:

Overall and carotid artery diameters > 95th percentile increased the risk for dementia by 1.74 (95% confidence interval [CI], 1.13–2.68) and 1.48 (95% CI, 1.12–1.96) fold, respectively. For stroke, meta-analyses yielded HRs of 1.59 (95% CI, 1.04–2.42) for overall arteries and 2.11 (95% CI, 1.45–3.08) for basilar artery diameters > 95th percentile.

DISCUSSION:

Individuals with dilated brain arteries are at higher risk for dementia and stroke, across distinct populations. Our findings underline the potential value of T2-weighted brain MRI-based brain diameter assessment in estimating the risk of dementia and stroke.

Original language	English
Pages (from-to)	2497-2507
Number of pages	11
Journal	Alzheimer's and Dementia
Volume	20
Issue number	4
Early online date	8 Feb 2024
DOIs	https://doi.org/10.1002/alz.13712
Publication status	Published - Apr 2024

Bibliographical note

Publisher Copyright:
© 2024 The Authors. Alzheimer's & Dementia published by Wiley Periodicals LLC on behalf of Alzheimer's Association.

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1002/alz.13712Licence: CC BY-NC-ND

Brain artery diameters and risk of dementia and strokeFinal published version, 457 KBLicence: CC BY-NC-ND

Cite this

Melgarejo, J. D., Gurel, K., Compton, C. R., Liu, M., Guzman, V., Assuras, S., Levin, B. E., Elkind, M. S. V., Ikram, M. K., Kavousi, M., Ikram, M. A., Wright, C., Crivello, F., Laurent, A., Tzourio, C., Vernooij, M. W., Rundek, T., Zhang, Z. Y., Bos, D., & Gutierrez, J. (2024). Brain artery diameters and risk of dementia and stroke. Alzheimer's and Dementia, 20(4), 2497-2507. https://doi.org/10.1002/alz.13712

@article{b3a954a3a1414acc9f35bacc8a4d9c8f,

title = "Brain artery diameters and risk of dementia and stroke",

abstract = "INTRODUCTION: We tested the association of brain artery diameters with dementia and stroke risk in three distinct population-based studies using conventional T2-weighted brain magnetic resonance imaging (MRI) images.METHODS: We included 8420 adults > 40 years old from three longitudinal population-based studies with brain MRI scans. We estimated and meta-analyzed the hazard ratios (HRs) of the brain and carotids and basilar diameters associated with dementia and stroke. RESULT: Overall and carotid artery diameters > 95th percentile increased the risk for dementia by 1.74 (95\% confidence interval [CI], 1.13–2.68) and 1.48 (95\% CI, 1.12–1.96) fold, respectively. For stroke, meta-analyses yielded HRs of 1.59 (95\% CI, 1.04–2.42) for overall arteries and 2.11 (95\% CI, 1.45–3.08) for basilar artery diameters > 95th percentile. DISCUSSION: Individuals with dilated brain arteries are at higher risk for dementia and stroke, across distinct populations. Our findings underline the potential value of T2-weighted brain MRI-based brain diameter assessment in estimating the risk of dementia and stroke.",

author = "Melgarejo, \{Jesus D.\} and Kursat Gurel and Compton, \{Cassidy Rose\} and Minghua Liu and Vanessa Guzman and Stephanie Assuras and Levin, \{Bonnie E.\} and Elkind, \{Mitchell S.V.\} and Ikram, \{M. Kamran\} and Maryam Kavousi and Ikram, \{M. Arfan\} and Clinton Wright and Fabrice Crivello and Alexandre Laurent and Christophe Tzourio and Vernooij, \{Meike W.\} and Tatjana Rundek and Zhang, \{Zhen Yu\} and Daniel Bos and Jose Gutierrez",

note = "Publisher Copyright: {\textcopyright} 2024 The Authors. Alzheimer's \& Dementia published by Wiley Periodicals LLC on behalf of Alzheimer's Association.",

year = "2024",

month = apr,

doi = "10.1002/alz.13712",

language = "English",

volume = "20",

pages = "2497--2507",

journal = "Alzheimer's and Dementia",

issn = "1552-5260",

publisher = "John Wiley \& Sons Inc.",

number = "4",

}

Melgarejo, JD, Gurel, K, Compton, CR, Liu, M, Guzman, V, Assuras, S, Levin, BE, Elkind, MSV, Ikram, MK , Kavousi, M , Ikram, MA, Wright, C, Crivello, F, Laurent, A, Tzourio, C, Vernooij, MW, Rundek, T, Zhang, ZY, Bos, D & Gutierrez, J 2024, 'Brain artery diameters and risk of dementia and stroke', Alzheimer's and Dementia, vol. 20, no. 4, pp. 2497-2507. https://doi.org/10.1002/alz.13712

TY - JOUR

T1 - Brain artery diameters and risk of dementia and stroke

AU - Melgarejo, Jesus D.

AU - Gurel, Kursat

AU - Compton, Cassidy Rose

AU - Liu, Minghua

AU - Guzman, Vanessa

AU - Assuras, Stephanie

AU - Levin, Bonnie E.

AU - Elkind, Mitchell S.V.

AU - Ikram, M. Kamran

AU - Kavousi, Maryam

AU - Ikram, M. Arfan

AU - Wright, Clinton

AU - Crivello, Fabrice

AU - Laurent, Alexandre

AU - Tzourio, Christophe

AU - Vernooij, Meike W.

AU - Rundek, Tatjana

AU - Zhang, Zhen Yu

AU - Bos, Daniel

AU - Gutierrez, Jose

PY - 2024/4

Y1 - 2024/4

N2 - INTRODUCTION: We tested the association of brain artery diameters with dementia and stroke risk in three distinct population-based studies using conventional T2-weighted brain magnetic resonance imaging (MRI) images.METHODS: We included 8420 adults > 40 years old from three longitudinal population-based studies with brain MRI scans. We estimated and meta-analyzed the hazard ratios (HRs) of the brain and carotids and basilar diameters associated with dementia and stroke. RESULT: Overall and carotid artery diameters > 95th percentile increased the risk for dementia by 1.74 (95% confidence interval [CI], 1.13–2.68) and 1.48 (95% CI, 1.12–1.96) fold, respectively. For stroke, meta-analyses yielded HRs of 1.59 (95% CI, 1.04–2.42) for overall arteries and 2.11 (95% CI, 1.45–3.08) for basilar artery diameters > 95th percentile. DISCUSSION: Individuals with dilated brain arteries are at higher risk for dementia and stroke, across distinct populations. Our findings underline the potential value of T2-weighted brain MRI-based brain diameter assessment in estimating the risk of dementia and stroke.

AB - INTRODUCTION: We tested the association of brain artery diameters with dementia and stroke risk in three distinct population-based studies using conventional T2-weighted brain magnetic resonance imaging (MRI) images.METHODS: We included 8420 adults > 40 years old from three longitudinal population-based studies with brain MRI scans. We estimated and meta-analyzed the hazard ratios (HRs) of the brain and carotids and basilar diameters associated with dementia and stroke. RESULT: Overall and carotid artery diameters > 95th percentile increased the risk for dementia by 1.74 (95% confidence interval [CI], 1.13–2.68) and 1.48 (95% CI, 1.12–1.96) fold, respectively. For stroke, meta-analyses yielded HRs of 1.59 (95% CI, 1.04–2.42) for overall arteries and 2.11 (95% CI, 1.45–3.08) for basilar artery diameters > 95th percentile. DISCUSSION: Individuals with dilated brain arteries are at higher risk for dementia and stroke, across distinct populations. Our findings underline the potential value of T2-weighted brain MRI-based brain diameter assessment in estimating the risk of dementia and stroke.

UR - http://www.scopus.com/inward/record.url?scp=85184456868&partnerID=8YFLogxK

U2 - 10.1002/alz.13712

DO - 10.1002/alz.13712

M3 - Article

C2 - 38332543

AN - SCOPUS:85184456868

SN - 1552-5260

VL - 20

SP - 2497

EP - 2507

JO - Alzheimer's and Dementia

JF - Alzheimer's and Dementia

IS - 4

ER -

Brain artery diameters and risk of dementia and stroke

Abstract

Bibliographical note

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this