Brain lesions in patients with multiple sclerosis: Detection with echo- planar imaging

B. Siewert*, M. R. Patel, M. F. Mueller, J. Gaa, D. G. Darby, C. M. Poser, P. A. Wielopolski, R. R. Edelman, S. Warach

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

29 Citations (Scopus)


PURPOSE: To evaluate the detection of brain lesions with echo-planar imaging relative to conventional spin-echo (SE) imaging. MATERIALS AND METHODS: In 17 patients (three men, 14 women; mean age, 31 years) with multiple sclerosis, the following were compared: single-shot proton-density- and T2-weighted and thin-section T2-weighted echo-planar, proton-density- and T2-weighted multishot echo-planar, and conventional SE sequences. Quantitative and qualitative criteria as well as lesion detectability were evaluated. The proton-density-weighted SE sequence was used as the standard of reference. RESULTS: Multishot sequences were superior to single-shot sequences in image quality and lesion detectability. With the multishot proton-density-weighted sequence, 53 of 54 large lesions and 23 of 30 small lesions were detected; with the single-shot proton-density-weighted sequence, 38 of 54 large lesions and five of 30 small lesions were detected. CONCLUSION: With multishot echo-planar sequences, detectability of large lesions is similar to that with conventional SE imaging. Susceptibility artifact is diminished in comparison to single-shot echo-planar sequences.

Original languageEnglish
Pages (from-to)765-771
Number of pages7
Issue number3
Publication statusPublished - 1995
Externally publishedYes


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