Brain volume changes in the first year of illness and 5-year outcome of schizophrenia

W. Cahn*, N. E.M. Van Haren, H. E. Hulshoff Pol, H. G. Schnack, E. Caspers, D. A.J. Laponder, R. S. Kahn

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

110 Citations (Scopus)


Progressive brain volume changes have been reported in first-episode schizophrenia, but their relationship to the disease process or to other factors remains unclear. We examined such changes in the first year of illness, and related them to 5-year outcome. Progressive brain volume changes, in particular of grey matter, during the first year of illness were found to be significantly associated with clinical and functional outcome 5 years after the first episode. These findings suggest that early dynamic brain volume changes are related to the disease process and predict the longer-term outcome of schizophrenia. Declaration of interest None.

Original languageEnglish
Pages (from-to)381-382
Number of pages2
JournalBritish Journal of Psychiatry
Issue numberOCT.
Publication statusPublished - Oct 2006
Externally publishedYes


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