Brain volume changes in the first year of illness and 5-year outcome of schizophrenia

W. Cahn; N. E.M. Van Haren; H. E. Hulshoff Pol; H. G. Schnack; E. Caspers; D. A.J. Laponder; R. S. Kahn

doi:10.1192/bjp.bp.105.015701

Brain volume changes in the first year of illness and 5-year outcome of schizophrenia

W. Cahn^*, N. E.M. Van Haren, H. E. Hulshoff Pol, H. G. Schnack, E. Caspers, D. A.J. Laponder, R. S. Kahn

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

110 Citations (Scopus)

Abstract

Progressive brain volume changes have been reported in first-episode schizophrenia, but their relationship to the disease process or to other factors remains unclear. We examined such changes in the first year of illness, and related them to 5-year outcome. Progressive brain volume changes, in particular of grey matter, during the first year of illness were found to be significantly associated with clinical and functional outcome 5 years after the first episode. These findings suggest that early dynamic brain volume changes are related to the disease process and predict the longer-term outcome of schizophrenia. Declaration of interest None.

Original language	English
Pages (from-to)	381-382
Number of pages	2
Journal	British Journal of Psychiatry
Volume	189
Issue number	OCT.
DOIs	https://doi.org/10.1192/bjp.bp.105.015701
Publication status	Published - Oct 2006
Externally published	Yes

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title = "Brain volume changes in the first year of illness and 5-year outcome of schizophrenia",

abstract = "Progressive brain volume changes have been reported in first-episode schizophrenia, but their relationship to the disease process or to other factors remains unclear. We examined such changes in the first year of illness, and related them to 5-year outcome. Progressive brain volume changes, in particular of grey matter, during the first year of illness were found to be significantly associated with clinical and functional outcome 5 years after the first episode. These findings suggest that early dynamic brain volume changes are related to the disease process and predict the longer-term outcome of schizophrenia. Declaration of interest None.",

author = "W. Cahn and {Van Haren}, {N. E.M.} and {Hulshoff Pol}, {H. E.} and Schnack, {H. G.} and E. Caspers and Laponder, {D. A.J.} and Kahn, {R. S.}",

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AU - Cahn, W.

AU - Van Haren, N. E.M.

AU - Hulshoff Pol, H. E.

AU - Schnack, H. G.

AU - Caspers, E.

AU - Laponder, D. A.J.

AU - Kahn, R. S.

PY - 2006/10

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N2 - Progressive brain volume changes have been reported in first-episode schizophrenia, but their relationship to the disease process or to other factors remains unclear. We examined such changes in the first year of illness, and related them to 5-year outcome. Progressive brain volume changes, in particular of grey matter, during the first year of illness were found to be significantly associated with clinical and functional outcome 5 years after the first episode. These findings suggest that early dynamic brain volume changes are related to the disease process and predict the longer-term outcome of schizophrenia. Declaration of interest None.

AB - Progressive brain volume changes have been reported in first-episode schizophrenia, but their relationship to the disease process or to other factors remains unclear. We examined such changes in the first year of illness, and related them to 5-year outcome. Progressive brain volume changes, in particular of grey matter, during the first year of illness were found to be significantly associated with clinical and functional outcome 5 years after the first episode. These findings suggest that early dynamic brain volume changes are related to the disease process and predict the longer-term outcome of schizophrenia. Declaration of interest None.

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JO - British Journal of Psychiatry

JF - British Journal of Psychiatry

SN - 0007-1250

IS - OCT.

ER -

Brain volume changes in the first year of illness and 5-year outcome of schizophrenia

Abstract

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