TY - JOUR
T1 - Bringing evolutionary cancer therapy to the clinic
T2 - a systems approach
AU - Soboleva, Arina
AU - Grossmann, Irene
AU - Dingemans, Anne-Marie C.
AU - Rezaei, Jafar
AU - Stankova, Katerina
N1 - Publisher Copyright:
© The Author(s) 2025.
PY - 2025/5/27
Y1 - 2025/5/27
N2 - Evolutionary cancer therapy (ECT) delays or forestalls the progression of metastatic cancer by adjusting treatment based on individual patient and disease characteristics. Clinical implementation of ECT can improve patient outcomes but faces technical and cultural challenges. To address those, we propose a systems approach incorporating systems modeling, problem structuring, and stakeholder engagement. This approach identifies and addresses barriers to implementation, ensuring the feasibility of ECT in clinical practice and enabling better metastatic cancer care.
AB - Evolutionary cancer therapy (ECT) delays or forestalls the progression of metastatic cancer by adjusting treatment based on individual patient and disease characteristics. Clinical implementation of ECT can improve patient outcomes but faces technical and cultural challenges. To address those, we propose a systems approach incorporating systems modeling, problem structuring, and stakeholder engagement. This approach identifies and addresses barriers to implementation, ensuring the feasibility of ECT in clinical practice and enabling better metastatic cancer care.
UR - https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=eur_pure&SrcAuth=WosAPI&KeyUT=WOS:001497134100001&DestLinkType=FullRecord&DestApp=WOS_CPL
U2 - 10.1038/s41540-025-00528-8
DO - 10.1038/s41540-025-00528-8
M3 - Review article
C2 - 40425536
SN - 2056-7189
VL - 11
JO - npj Systems Biology and Applications
JF - npj Systems Biology and Applications
IS - 1
M1 - 56
ER -
