Burden of norovirus in healthcare facilities and strategies for outbreak control

A Kambhampati, Marion Koopmans, BA Lopman

Research output: Contribution to journalArticleAcademicpeer-review

64 Citations (Scopus)

Abstract

Norovirus is the most frequently occurring cause of community-acquired acute gastroenteritis in people of all ages. It is also one of the most frequent causes of outbreaks in healthcare settings, affecting both long-term care facilities and acute care hospitals. Whereas norovirus gastroenteritis is typically mild and resolves without medical attention, healthcare-associated infections often affect vulnerable populations, resulting in severe infections and disruption of healthcare services. Globally, most norovirus outbreaks in hospitals and residential care institutions are associated with genogroup II type 4 (GII.4) strains. Recent data demonstrate that excess mortality occurs during outbreak periods in healthcare facilities. Nosocomial outbreaks can result in large economic and societal costs. Current control measures for norovirus are largely based on general infection control principles, and treatment is mainly supportive and non-specific. While neither vaccines nor antiviral agents are currently available, both are being developed with encouraging results. Published by Elsevier Ltd on behalf of the Healthcare Infection Society.
Original languageUndefined/Unknown
Pages (from-to)296-301
Number of pages6
JournalJournal of Hospital Infection
Volume89
Issue number4
DOIs
Publication statusPublished - 2015

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