Cam morphology is strongly and consistently associated with development of radiographic hip osteoarthritis throughout 4 follow-up visits within 10 years

Jinchi Tang; Michiel M.A. van Buuren; Noortje S. Riedstra; Fleur Boel; Jos Runhaar; Sita Bierma-Zeinstra; Rintje Agricola

doi:10.1016/j.joca.2023.08.006

Cam morphology is strongly and consistently associated with development of radiographic hip osteoarthritis throughout 4 follow-up visits within 10 years

Jinchi Tang^*, Michiel M.A. van Buuren, Noortje S. Riedstra, Fleur Boel, Jos Runhaar, Sita Bierma-Zeinstra, Rintje Agricola

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

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Abstract

Objective:

To determine the association between cam morphology and the development of radiographic hip osteoarthritis (RHOA) at four time points within 10-year follow-up.

Design:

The nationwide prospective Cohort Hip and Cohort Knee study includes 1002 participants aged 45–65 years with 2-, 5-, 8-, and 10-year follow-ups. The associations of cam morphology (alpha angle >60°) and large cam morphology (alpha angle >78°) in hips free of osteoarthritis at baseline (Kellgren & Lawrence (KL) grade <2) with the development of both incident RHOA (KL grade≥2) and end-stage RHOA (KL grade≥3) were estimated using logistic regression with generalized estimating equation at each follow-up and using Cox regression over 10 years, adjusted for age, sex, and body mass index.

Results:

Both cam morphology and large cam morphology were associated with the development of incident RHOA at all follow-ups with adjusted Odd Ratios (aORs) ranging from 2.7 (95% Confidence interval 1.8–4.1) to 2.9 (95% CI 2.0–4.4) for cam morphology and ranging from 2.5 (95% CI 1.5–4.3) to 4.2 (95% CI 2.2–8.3) for large cam morphology. For end-stage RHOA, cam morphology resulted in aORs ranging from 4.9 (95% CI 1.8–13.2) to 8.5 (95% CI 1.1–64.4), and aORs for large cam morphology ranged from 6.7 (95% CI 3.1–14.7) to 12.7 (95% CI 1.9–84.4).

Conclusions:

Cam morphology poses the hip at 2–13 times increased odds for developing RHOA within a 10-year follow-up. The association was particularly strong for large cam morphology and end-stage RHOA, while the strength of association was consistent over time.

Original language	English
Pages (from-to)	1650-1656
Number of pages	7
Journal	Osteoarthritis and Cartilage
Volume	31
Issue number	12
Early online date	18 Aug 2023
DOIs	https://doi.org/10.1016/j.joca.2023.08.006
Publication status	Published - Dec 2023

Bibliographical note

Funding Information:
The CHECK study was funded by the Dutch Arthritis Association. The author was funded by China Scholarship Council with grant number: 202006170050 .

Publisher Copyright:
© 2023 The Authors

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1-s2.0-S1063458423008907-mainFinal published version, 2.03 MBLicence: CC BY

Cite this

@article{ddd74a4bb4e643fd843eee52c1edb023,

title = "Cam morphology is strongly and consistently associated with development of radiographic hip osteoarthritis throughout 4 follow-up visits within 10 years",

abstract = "Objective: To determine the association between cam morphology and the development of radiographic hip osteoarthritis (RHOA) at four time points within 10-year follow-up. Design: The nationwide prospective Cohort Hip and Cohort Knee study includes 1002 participants aged 45–65 years with 2-, 5-, 8-, and 10-year follow-ups. The associations of cam morphology (alpha angle >60°) and large cam morphology (alpha angle >78°) in hips free of osteoarthritis at baseline (Kellgren & Lawrence (KL) grade <2) with the development of both incident RHOA (KL grade≥2) and end-stage RHOA (KL grade≥3) were estimated using logistic regression with generalized estimating equation at each follow-up and using Cox regression over 10 years, adjusted for age, sex, and body mass index.Results: Both cam morphology and large cam morphology were associated with the development of incident RHOA at all follow-ups with adjusted Odd Ratios (aORs) ranging from 2.7 (95% Confidence interval 1.8–4.1) to 2.9 (95% CI 2.0–4.4) for cam morphology and ranging from 2.5 (95% CI 1.5–4.3) to 4.2 (95% CI 2.2–8.3) for large cam morphology. For end-stage RHOA, cam morphology resulted in aORs ranging from 4.9 (95% CI 1.8–13.2) to 8.5 (95% CI 1.1–64.4), and aORs for large cam morphology ranged from 6.7 (95% CI 3.1–14.7) to 12.7 (95% CI 1.9–84.4). Conclusions: Cam morphology poses the hip at 2–13 times increased odds for developing RHOA within a 10-year follow-up. The association was particularly strong for large cam morphology and end-stage RHOA, while the strength of association was consistent over time.",

author = "Jinchi Tang and {van Buuren}, {Michiel M.A.} and Riedstra, {Noortje S.} and Fleur Boel and Jos Runhaar and Sita Bierma-Zeinstra and Rintje Agricola",

note = "Funding Information: The CHECK study was funded by the Dutch Arthritis Association. The author was funded by China Scholarship Council with grant number: 202006170050 . Publisher Copyright: {\textcopyright} 2023 The Authors",

year = "2023",

month = dec,

doi = "10.1016/j.joca.2023.08.006",

language = "English",

volume = "31",

pages = "1650--1656",

journal = "Osteoarthritis and Cartilage",

issn = "1063-4584",

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Cam morphology is strongly and consistently associated with development of radiographic hip osteoarthritis throughout 4 follow-up visits within 10 years. / Tang, Jinchi ; van Buuren, Michiel M.A.; Riedstra, Noortje S. et al.
In: Osteoarthritis and Cartilage, Vol. 31, No. 12, 12.2023, p. 1650-1656.

Research output: Contribution to journal › Article › Academic › peer-review

TY - JOUR

T1 - Cam morphology is strongly and consistently associated with development of radiographic hip osteoarthritis throughout 4 follow-up visits within 10 years

AU - Tang, Jinchi

AU - van Buuren, Michiel M.A.

AU - Riedstra, Noortje S.

AU - Boel, Fleur

AU - Runhaar, Jos

AU - Bierma-Zeinstra, Sita

AU - Agricola, Rintje

N1 - Funding Information: The CHECK study was funded by the Dutch Arthritis Association. The author was funded by China Scholarship Council with grant number: 202006170050 . Publisher Copyright: © 2023 The Authors

PY - 2023/12

Y1 - 2023/12

N2 - Objective: To determine the association between cam morphology and the development of radiographic hip osteoarthritis (RHOA) at four time points within 10-year follow-up. Design: The nationwide prospective Cohort Hip and Cohort Knee study includes 1002 participants aged 45–65 years with 2-, 5-, 8-, and 10-year follow-ups. The associations of cam morphology (alpha angle >60°) and large cam morphology (alpha angle >78°) in hips free of osteoarthritis at baseline (Kellgren & Lawrence (KL) grade <2) with the development of both incident RHOA (KL grade≥2) and end-stage RHOA (KL grade≥3) were estimated using logistic regression with generalized estimating equation at each follow-up and using Cox regression over 10 years, adjusted for age, sex, and body mass index.Results: Both cam morphology and large cam morphology were associated with the development of incident RHOA at all follow-ups with adjusted Odd Ratios (aORs) ranging from 2.7 (95% Confidence interval 1.8–4.1) to 2.9 (95% CI 2.0–4.4) for cam morphology and ranging from 2.5 (95% CI 1.5–4.3) to 4.2 (95% CI 2.2–8.3) for large cam morphology. For end-stage RHOA, cam morphology resulted in aORs ranging from 4.9 (95% CI 1.8–13.2) to 8.5 (95% CI 1.1–64.4), and aORs for large cam morphology ranged from 6.7 (95% CI 3.1–14.7) to 12.7 (95% CI 1.9–84.4). Conclusions: Cam morphology poses the hip at 2–13 times increased odds for developing RHOA within a 10-year follow-up. The association was particularly strong for large cam morphology and end-stage RHOA, while the strength of association was consistent over time.

AB - Objective: To determine the association between cam morphology and the development of radiographic hip osteoarthritis (RHOA) at four time points within 10-year follow-up. Design: The nationwide prospective Cohort Hip and Cohort Knee study includes 1002 participants aged 45–65 years with 2-, 5-, 8-, and 10-year follow-ups. The associations of cam morphology (alpha angle >60°) and large cam morphology (alpha angle >78°) in hips free of osteoarthritis at baseline (Kellgren & Lawrence (KL) grade <2) with the development of both incident RHOA (KL grade≥2) and end-stage RHOA (KL grade≥3) were estimated using logistic regression with generalized estimating equation at each follow-up and using Cox regression over 10 years, adjusted for age, sex, and body mass index.Results: Both cam morphology and large cam morphology were associated with the development of incident RHOA at all follow-ups with adjusted Odd Ratios (aORs) ranging from 2.7 (95% Confidence interval 1.8–4.1) to 2.9 (95% CI 2.0–4.4) for cam morphology and ranging from 2.5 (95% CI 1.5–4.3) to 4.2 (95% CI 2.2–8.3) for large cam morphology. For end-stage RHOA, cam morphology resulted in aORs ranging from 4.9 (95% CI 1.8–13.2) to 8.5 (95% CI 1.1–64.4), and aORs for large cam morphology ranged from 6.7 (95% CI 3.1–14.7) to 12.7 (95% CI 1.9–84.4). Conclusions: Cam morphology poses the hip at 2–13 times increased odds for developing RHOA within a 10-year follow-up. The association was particularly strong for large cam morphology and end-stage RHOA, while the strength of association was consistent over time.

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DO - 10.1016/j.joca.2023.08.006

M3 - Article

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SN - 1063-4584

VL - 31

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JO - Osteoarthritis and Cartilage

JF - Osteoarthritis and Cartilage

IS - 12

ER -

Cam morphology is strongly and consistently associated with development of radiographic hip osteoarthritis throughout 4 follow-up visits within 10 years

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