Abstract
The pathogenesis of hidradenitis suppurativa (HS) is still enigmatic, and a valid animal model for HS is currently not available. The recent discovery of gamma-secretase mutations in a subpopulation of patients with HS suggested gamma-secretase transgenic mice as a model for HS pathogenesis. However, the discrepancies between human HS and these mice are daunting. We critically review cases of animal HS and transgenic gamma-secretase mouse models for HS and discuss the criteria which should be met for a representative pathogenic model. Copyright (C) 2012 S. Karger AG, Basel
| Original language | Undefined/Unknown |
|---|---|
| Pages (from-to) | 9-13 |
| Number of pages | 5 |
| Journal | Dermatology |
| Volume | 225 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - 2012 |
Research programs
- EMC MM-02-72-02
- EMC MM-03-61-05-A