Cardiac motion-corrected iterative cone-beam CT reconstruction using a semi-automatic minimum cost path-based coronary centerline extraction

Alfonso Isola, Coert Metz, Michiel Schaap, Stefan Klein, M Grass, Wiro Niessen

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14 Citations (Scopus)


In this paper a method which combines iterative computed tomography reconstruction and coronary centerline extraction technique to obtain motion artifact-free reconstructed images of the coronary arteries are proposed and evaluated. The method relies on motion-vector fields derived from a set of coronary centerlines extracted at multiple cardiac phases within the R-R interval. Hereto, start and end points are provided by the user in one time-frame only. Using an elastic image registration, these points are propagated to all the remaining cardiac phases. Consequently, a multi-phase three-dimensional coronary centerline is determined by applying a semi-automatic minimum cost path based extraction method. Corresponding centerline positions are used to determine the relative motion-vector fields from phase to phase. Finally, dense motion-vector fields are achieved by thin-plate-spline interpolation and used to perform a motion-corrected iterative reconstruction of a selected region of interest. The performance of the method is validated on five patients, showing the improved sharpness of cardiac motion-corrected gated iterative reconstructions compared to the results achieved by a classical gated iterative method. The results are also compared to known manual and fully automatic coronary artery motion estimation methods. (C) 2012 Elsevier Ltd. All rights reserved.
Original languageUndefined/Unknown
Pages (from-to)215-226
Number of pages12
JournalComputerized Medical Imaging and Graphics
Issue number3
Publication statusPublished - 2012

Research programs

  • EMC COEUR-09
  • EMC NIHES-03-30-03

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