Cardiovascular health, genetic predisposition, and lifetime risk of type 2 diabetes

Kan Wang, Maryam Kavousi, Trudy Voortman, M. Arfan Ikram, Mohsen Ghanbari, Fariba Ahmadizar*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

5 Citations (Scopus)
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Abstract

Aims: Data on the lifetime risk of type 2 diabetes (T2D) incidence across different cardiovascular health (CVH) categories are scarce. Moreover, it remains unclear whether a genetic predisposition modifies this association. Methods and results: Using data from the prospective population-based Rotterdam Study, a CVH score (body mass index, blood pressure, total cholesterol, smoking status, diet, and physical activity) was calculated and further categorized at baseline. Genetic predisposition to T2D was assessed and divided into tertiles by creating a genetic risk score (GRS). We estimated the lifetime risk for T2D within different CVH and GRS categories. Among 5993 individuals free of T2D at baseline [mean (standard deviation) age, 69.1 (8.5) years; 58% female], 869 individuals developed T2D during follow-up. At age 55 years, the remaining lifetime risk of T2D was 22.6% (95% CI: 19.4-25.8) for ideal, 28.3% (25.8-30.8) for intermediate, and 32.6% (29.0-36.2) for poor CVH. After further stratification by GRS tertiles, the lifetime risk for T2D was still the lowest for ideal CVH in the lowest GRS tertiles [21.5% (13.7-29.3)], in the second GRS tertile [20.8% (15.9-25.8)], and in the highest tertile [23.5% (18.5-28.6)] when compared with poor and intermediate CVH. Conclusion: Our results highlight the importance of favourable CVH in preventing T2D among middle-aged individuals regardless of their genetic predisposition.

Original languageEnglish
Pages (from-to)1850-1857
Number of pages8
JournalEuropean Journal of Preventive Cardiology
Volume28
Issue number16
DOIs
Publication statusPublished - 9 Sep 2021

Bibliographical note

Funding Information:
Erasmus MC and Erasmus University Rotterdam; Netherlands Organization for Scientific Research; Netherlands Organization for Health Research and Development (ZonMw); Research Institute for Diseases in the Elderly; Netherlands Genomics Initiative; Netherlands Ministry of Education, Culture and Science; Netherlands Ministry of Health, Welfare and Sports; European Commission; and Municipality of Rotterdam; ZonMw VENI grant (91616079-M.K.). This manuscript is also part of a project that has received funding from the Innovative Medicine Initiative 2 Joint Undertaking under grant agreement No 875534. This Joint Undertaking support from the European Union's Horizon 2020 research and innovation programme and EFPIA and T1D Exchange, JDRF, and Obesity Action Coalition. We would also like to thank the China Scholarship Council for the scholarship to K.W.

Publisher Copyright: © 2021 The Author(s).

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