Carotid plaque elasticity estimation using ultrasound elastography, MRI, and inverse FEA - A numerical feasibility study

Harm Nieuwstadt, S Fekkes, HHG Hansen, CL (Chris) de Korte, Aad van der Lugt, Jolanda Wentzel, Ton van der Steen, Frank Gijsen

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Abstract

The material properties of atherosclerotic plaques govern the biomechanical environment, which is associated with rupture-risk. We investigated the feasibility of noninvasively estimating carotid plaque component material properties through simulating ultrasound (US) elastography and in vivo magnetic resonance imaging (MRI), and solving the inverse problem with finite element analysis. 2D plaque models were derived from endarterectomy specimens of nine patients. Nonlinear neo-Hookean models (tissue elasticity C-1) were assigned to fibrous intima, wall (i.e., media/adventitia), and lipid-rich necrotic core. Finite element analysis was used to simulate clinical cross-sectional US strain imaging. Computer-simulated, single-slice in vivo MR images were segmented by two MR readers. We investigated multiple scenarios for plaque model elasticity, and consistently found clear separations between estimated tissue elasticity values. The intima C-1 (160 kPa scenario) was estimated as 125.8 +/- 19.4 kPa (reader 1) and 128.9 +/- 24.8 kPa (reader 2). The lipid-rich necrotic core C-1 (5 kPa) was estimated as 5.6 +/- 2.0 kPa (reader 1) and 8.5 +/- 4.5 kPa (reader 2). A scenario with a stiffer wall yielded similar results, while realistic US strain noise and rotating the models had little influence, thus demonstrating robustness of the procedure. The promising findings of this computer-simulation study stimulate applying the proposed methodology in a clinical setting. (C) 2015 IPEM. Published by Elsevier Ltd. All rights reserved.
Original languageUndefined/Unknown
Pages (from-to)801-807
Number of pages7
JournalMedical Engineering & Physics
Volume37
Issue number8
DOIs
Publication statusPublished - 2015

Research programs

  • EMC COEUR-09

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