Case Report: Late Reactivation of Herpes B Virus After a Monkey Bite: A Case of Severe Meningoencephalitis

Ester Ponzetto, Quentin Delhez, Maarten Hoppenbrouwers, Nicolas De Schryver, Nicolas Serck, Thierry Dugernier, Marie Céline Duray, Benjamin Gressens, Marco Vinetti, Gregorius J. Sips, Jeroen van Kampen, Corine H. GeurtsvanKessel, Sander van Boheemen

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Abstract

Macacine alphaherpesvirus 1, also known as herpes B virus (BV), is an alphaherpesvirus endemic to several macaque species, capable of causing zoonotic infections in humans, with high mortality rates. Evidence of reactivation in humans has rarely been reported. Here we depict a case of BV reactivation after 54 years, leading to severe meningoencephalitis. This case supports the use of antiviral prophylaxis in patients surviving a confirmed BV central nervous system infection. We sequenced DNA from BV obtained from the patient's cerebrospinal fluid. Phylogenetic analysis showed significant divergence in the clustering of this particular BV strain compared with other known BVs. Therefore, additional efforts are needed to obtain a broader sequence landscape from BVs circulating in monkeys.

Original languageEnglish
Pages (from-to)1277-1281
Number of pages5
JournalThe American journal of tropical medicine and hygiene
Volume109
Issue number6
DOIs
Publication statusPublished - 6 Dec 2023

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