Case Report: Supernormal Vascular Aging in Leningrad Siege Survivors

Oxana Rotar; Maria Boyarinova; Ekaterina Moguchaya; Kristina Tolkunova; Nikita Kolosov; Valeriia Rezapova; Olga Freylikhman; Dmitrii Usoltsev; Olesya Melnik; Alexey Sergushichev; Vladislav Solntsev; Anna Kostareva; Elena Dubinina; Trudy Voortman; Christine Stevens; Mark J. Daly; Alexandra Konradi; Evgeny Shlyakhto; Mykyta Artomov

doi:10.3389/fcvm.2022.843439

Case Report: Supernormal Vascular Aging in Leningrad Siege Survivors

Oxana Rotar, Maria Boyarinova, Ekaterina Moguchaya, Kristina Tolkunova, Nikita Kolosov, Valeriia Rezapova, Olga Freylikhman, Dmitrii Usoltsev, Olesya Melnik, Alexey Sergushichev, Vladislav Solntsev, Anna Kostareva, Elena Dubinina, Trudy Voortman, Christine Stevens, Mark J. Daly, Alexandra Konradi, Evgeny Shlyakhto, Mykyta Artomov^*

^*Corresponding author for this work

Epidemiology

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Abstract

Age-related changes in the vascular system play an important role in the biological age and lifespan of a person and maybe affected from an early age onward. One of the indicators of changes in the vascular system is arterial wall stiffness and its main measure, i.e., carotid-femoral pulse wave velocity (cfPWV). We examined arterial wall stiffness in a sample of 305 Leningrad Siege survivors to assess how hunger and stressful conditions during fetal development and early childhood affected the state of the cardiovascular system at a later age and what factors may neutralize the negative impact sustained in early childhood. Here, we presented an evaluation of two unique patients with supernormal vascular aging (SUPERNOVA) phenotype from this cohort and described the details of congruence between hereditary resistance and practiced lifestyle yielding slower biological aging rate.

Original language	English
Article number	843439
Journal	Frontiers in Cardiovascular Medicine
Volume	9
DOIs	https://doi.org/10.3389/fcvm.2022.843439
Publication status	Published - 23 May 2022

Bibliographical note

Funding Information:
OR, MB, EM, KT, NK, VR, OF, OM, AKos, AKon, and ES were supported by the Ministry of Science and Higher Education of the Russian Federation (Agreement No. 075-15-2022-301). CS and MD were supported by Broad Institute SPARK Award. MA was supported by funding from the Aging Biology Foundation.

Publisher Copyright:
Copyright © 2022 Rotar, Boyarinova, Moguchaya, Tolkunova, Kolosov, Rezapova, Freylikhman, Usoltsev, Melnik, Sergushichev, Solntsev, Kostareva, Dubinina, Voortman, Stevens, Daly, Konradi, Shlyakhto and Artomov.

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10.3389/fcvm.2022.843439Licence: CC BY

Case Report, Supernormal Vascular Aging in Leningrad Siege SurvivorsFinal published version, 482 KBLicence: CC BY

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Rotar, O., Boyarinova, M., Moguchaya, E., Tolkunova, K., Kolosov, N., Rezapova, V., Freylikhman, O., Usoltsev, D., Melnik, O., Sergushichev, A., Solntsev, V., Kostareva, A., Dubinina, E., Voortman, T., Stevens, C., Daly, M. J., Konradi, A., Shlyakhto, E., & Artomov, M. (2022). Case Report: Supernormal Vascular Aging in Leningrad Siege Survivors. Frontiers in Cardiovascular Medicine, 9, Article 843439. https://doi.org/10.3389/fcvm.2022.843439

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title = "Case Report: Supernormal Vascular Aging in Leningrad Siege Survivors",

abstract = "Age-related changes in the vascular system play an important role in the biological age and lifespan of a person and maybe affected from an early age onward. One of the indicators of changes in the vascular system is arterial wall stiffness and its main measure, i.e., carotid-femoral pulse wave velocity (cfPWV). We examined arterial wall stiffness in a sample of 305 Leningrad Siege survivors to assess how hunger and stressful conditions during fetal development and early childhood affected the state of the cardiovascular system at a later age and what factors may neutralize the negative impact sustained in early childhood. Here, we presented an evaluation of two unique patients with supernormal vascular aging (SUPERNOVA) phenotype from this cohort and described the details of congruence between hereditary resistance and practiced lifestyle yielding slower biological aging rate.",

author = "Oxana Rotar and Maria Boyarinova and Ekaterina Moguchaya and Kristina Tolkunova and Nikita Kolosov and Valeriia Rezapova and Olga Freylikhman and Dmitrii Usoltsev and Olesya Melnik and Alexey Sergushichev and Vladislav Solntsev and Anna Kostareva and Elena Dubinina and Trudy Voortman and Christine Stevens and Daly, {Mark J.} and Alexandra Konradi and Evgeny Shlyakhto and Mykyta Artomov",

note = "Funding Information: OR, MB, EM, KT, NK, VR, OF, OM, AKos, AKon, and ES were supported by the Ministry of Science and Higher Education of the Russian Federation (Agreement No. 075-15-2022-301). CS and MD were supported by Broad Institute SPARK Award. MA was supported by funding from the Aging Biology Foundation. Publisher Copyright: Copyright {\textcopyright} 2022 Rotar, Boyarinova, Moguchaya, Tolkunova, Kolosov, Rezapova, Freylikhman, Usoltsev, Melnik, Sergushichev, Solntsev, Kostareva, Dubinina, Voortman, Stevens, Daly, Konradi, Shlyakhto and Artomov.",

year = "2022",

month = may,

day = "23",

doi = "10.3389/fcvm.2022.843439",

language = "English",

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Rotar, O, Boyarinova, M, Moguchaya, E, Tolkunova, K, Kolosov, N, Rezapova, V, Freylikhman, O, Usoltsev, D, Melnik, O, Sergushichev, A, Solntsev, V, Kostareva, A, Dubinina, E, Voortman, T, Stevens, C, Daly, MJ, Konradi, A, Shlyakhto, E & Artomov, M 2022, 'Case Report: Supernormal Vascular Aging in Leningrad Siege Survivors', Frontiers in Cardiovascular Medicine, vol. 9, 843439. https://doi.org/10.3389/fcvm.2022.843439

TY - JOUR

T1 - Case Report

T2 - Supernormal Vascular Aging in Leningrad Siege Survivors

AU - Rotar, Oxana

AU - Boyarinova, Maria

AU - Moguchaya, Ekaterina

AU - Tolkunova, Kristina

AU - Kolosov, Nikita

AU - Rezapova, Valeriia

AU - Freylikhman, Olga

AU - Usoltsev, Dmitrii

AU - Melnik, Olesya

AU - Sergushichev, Alexey

AU - Solntsev, Vladislav

AU - Kostareva, Anna

AU - Dubinina, Elena

AU - Voortman, Trudy

AU - Stevens, Christine

AU - Daly, Mark J.

AU - Konradi, Alexandra

AU - Shlyakhto, Evgeny

AU - Artomov, Mykyta

N1 - Funding Information: OR, MB, EM, KT, NK, VR, OF, OM, AKos, AKon, and ES were supported by the Ministry of Science and Higher Education of the Russian Federation (Agreement No. 075-15-2022-301). CS and MD were supported by Broad Institute SPARK Award. MA was supported by funding from the Aging Biology Foundation. Publisher Copyright: Copyright © 2022 Rotar, Boyarinova, Moguchaya, Tolkunova, Kolosov, Rezapova, Freylikhman, Usoltsev, Melnik, Sergushichev, Solntsev, Kostareva, Dubinina, Voortman, Stevens, Daly, Konradi, Shlyakhto and Artomov.

PY - 2022/5/23

Y1 - 2022/5/23

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AN - SCOPUS:85138463996

SN - 2297-055X

VL - 9

JO - Frontiers in Cardiovascular Medicine

JF - Frontiers in Cardiovascular Medicine

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ER -

Case Report: Supernormal Vascular Aging in Leningrad Siege Survivors

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