TY - JOUR
T1 - Catheter-tip colonization as a surrogate end point in clinical studies on catheter-related bloodstream infection
T2 - How strong is the evidence?
AU - Rijnders, Bart J.A.
AU - Van Wijngaerden, Eric
AU - Peetermans, Willy E.
PY - 2002/11/1
Y1 - 2002/11/1
N2 - In clinical trials, the incidence of catheter-tip colonization (CTC) is frequently used as a surrogate end point for the incidence of catheter-related bloodstream infection (BSI). It is not clear whether the correlation between CTC and catheter-related BSI is good. We searched the MEDLINE database and conducted a literature search for the years 1990-2002 and retrieved 29 studies (with a total of 60 study groups) with incidence data on predefined CTC and catheter-related BSI definitions. A good linear correlation between CTC and catheter-related BSI was found (r = 0.69; r2 = 0.48; P<.001). The data from the medical literature about catheter-related infection seem to support the use of CTC as a surrogate end point for catheter-related BSI. In evaluations of clinical interventions or new techniques for the prevention of catheter-related BSI, investigation of the prevention of CTC seems to be a logical first step.
AB - In clinical trials, the incidence of catheter-tip colonization (CTC) is frequently used as a surrogate end point for the incidence of catheter-related bloodstream infection (BSI). It is not clear whether the correlation between CTC and catheter-related BSI is good. We searched the MEDLINE database and conducted a literature search for the years 1990-2002 and retrieved 29 studies (with a total of 60 study groups) with incidence data on predefined CTC and catheter-related BSI definitions. A good linear correlation between CTC and catheter-related BSI was found (r = 0.69; r2 = 0.48; P<.001). The data from the medical literature about catheter-related infection seem to support the use of CTC as a surrogate end point for catheter-related BSI. In evaluations of clinical interventions or new techniques for the prevention of catheter-related BSI, investigation of the prevention of CTC seems to be a logical first step.
UR - http://www.scopus.com/inward/record.url?scp=0036827766&partnerID=8YFLogxK
U2 - 10.1086/342905
DO - 10.1086/342905
M3 - Article
C2 - 12384838
AN - SCOPUS:0036827766
SN - 1058-4838
VL - 35
SP - 1053
EP - 1058
JO - Clinical Infectious Diseases
JF - Clinical Infectious Diseases
IS - 9
ER -