ccbe1 is required for embryonic lymphangiogenesis and venous sprouting

BM Hogan; Frank Bos; HJ Bussmann; M Witte; NC Chi; Eric Duckers; S Schulte-Merker

doi:10.1038/ng.321

ccbe1 is required for embryonic lymphangiogenesis and venous sprouting

BM Hogan, Frank Bos, HJ Bussmann, M Witte, NC Chi, Eric Duckers, S Schulte-Merker

Cardiology

Research output: Contribution to journal › Article › Academic › peer-review

375 Citations (Scopus)

Abstract

Lymphatic vessels have important roles in fluid homeostasis, fat absorption, inflammation and cancer metastasis and develop in a dynamic process (called lymphangiogenesis) involving budding, migration and proliferation of lymphangioblasts. Using a genetic screen in zebrafish we identify ccbe1 (collagen and calcium-binding EGF domain-1) as indispensible for embryonic lymphangiogenesis. Ccbe1 acts at the same stage of development as Vegfc and is required for lymphangioblast budding and angiogenic sprouting from venous endothelium.

Original language	Undefined/Unknown
Pages (from-to)	396-398
Number of pages	3
Journal	Nature Genetics
Volume	41
Issue number	4
DOIs	https://doi.org/10.1038/ng.321
Publication status	Published - 2009

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EMC COEUR-09

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This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1038/ng.321

http://hdl.handle.net/1765/16241

Cite this

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title = "ccbe1 is required for embryonic lymphangiogenesis and venous sprouting",

abstract = "Lymphatic vessels have important roles in fluid homeostasis, fat absorption, inflammation and cancer metastasis and develop in a dynamic process (called lymphangiogenesis) involving budding, migration and proliferation of lymphangioblasts. Using a genetic screen in zebrafish we identify ccbe1 (collagen and calcium-binding EGF domain-1) as indispensible for embryonic lymphangiogenesis. Ccbe1 acts at the same stage of development as Vegfc and is required for lymphangioblast budding and angiogenic sprouting from venous endothelium.",

author = "BM Hogan and Frank Bos and HJ Bussmann and M Witte and NC Chi and Eric Duckers and S Schulte-Merker",

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doi = "10.1038/ng.321",

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AU - Hogan, BM

AU - Bos, Frank

AU - Bussmann, HJ

AU - Witte, M

AU - Chi, NC

AU - Duckers, Eric

AU - Schulte-Merker, S

PY - 2009

Y1 - 2009

N2 - Lymphatic vessels have important roles in fluid homeostasis, fat absorption, inflammation and cancer metastasis and develop in a dynamic process (called lymphangiogenesis) involving budding, migration and proliferation of lymphangioblasts. Using a genetic screen in zebrafish we identify ccbe1 (collagen and calcium-binding EGF domain-1) as indispensible for embryonic lymphangiogenesis. Ccbe1 acts at the same stage of development as Vegfc and is required for lymphangioblast budding and angiogenic sprouting from venous endothelium.

AB - Lymphatic vessels have important roles in fluid homeostasis, fat absorption, inflammation and cancer metastasis and develop in a dynamic process (called lymphangiogenesis) involving budding, migration and proliferation of lymphangioblasts. Using a genetic screen in zebrafish we identify ccbe1 (collagen and calcium-binding EGF domain-1) as indispensible for embryonic lymphangiogenesis. Ccbe1 acts at the same stage of development as Vegfc and is required for lymphangioblast budding and angiogenic sprouting from venous endothelium.

U2 - 10.1038/ng.321

DO - 10.1038/ng.321

M3 - Article

C2 - 19287381

SN - 1061-4036

VL - 41

SP - 396

EP - 398

JO - Nature Genetics

JF - Nature Genetics

IS - 4

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