ccbe1 is required for embryonic lymphangiogenesis and venous sprouting

BM Hogan, Frank Bos, HJ Bussmann, M Witte, NC Chi, Eric Duckers, S Schulte-Merker

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Abstract

Lymphatic vessels have important roles in fluid homeostasis, fat absorption, inflammation and cancer metastasis and develop in a dynamic process (called lymphangiogenesis) involving budding, migration and proliferation of lymphangioblasts. Using a genetic screen in zebrafish we identify ccbe1 (collagen and calcium-binding EGF domain-1) as indispensible for embryonic lymphangiogenesis. Ccbe1 acts at the same stage of development as Vegfc and is required for lymphangioblast budding and angiogenic sprouting from venous endothelium.
Original languageUndefined/Unknown
Pages (from-to)396-398
Number of pages3
JournalNature Genetics
Volume41
Issue number4
DOIs
Publication statusPublished - 2009

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