Cd4+ t cells in chronic hepatitis b and t cell-directed immunotherapy

Sonja I. Buschow; Diahann T.S.L. Jansen

doi:10.3390/cells10051114

Cd4⁺ t cells in chronic hepatitis b and t cell-directed immunotherapy

Sonja I. Buschow^*, Diahann T.S.L. Jansen

^*Corresponding author for this work

Gastroenterology & Hepatology

Research output: Contribution to journal › Review article › Academic › peer-review

32 Citations (Scopus)

74 Downloads (Pure)

Abstract

The impaired T cell responses observed in chronic hepatitis B (HBV) patients are considered to contribute to the chronicity of the infection. Research on this impairment has been focused on CD8⁺ T cells because of their cytotoxic effector function; however, CD4⁺ T cells are crucial in the proper development of these long-lasting effector CD8⁺ T cells. In this review, we summarize what is known about CD4⁺ T cells in chronic HBV infection and discuss the importance and opportunities of including CD4⁺ T cells in T cell-directed immunotherapeutic strategies to cure chronic HBV.

Original language	English
Article number	1114
Journal	Cells
Volume	10
Issue number	5
DOIs	https://doi.org/10.3390/cells10051114
Publication status	Published - 6 May 2021

Bibliographical note

Funding: D.T.S.L.J. was funded by an internal Erasmus MC grant, grant number 2019-122. No
external funding was received.

Publisher Copyright: © 2021 by the authors. Licensee MDPI, Basel, Switzerland.

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.3390/cells10051114

cells-10-01114-v2Licence: CC BY

Cite this

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abstract = "The impaired T cell responses observed in chronic hepatitis B (HBV) patients are considered to contribute to the chronicity of the infection. Research on this impairment has been focused on CD8+ T cells because of their cytotoxic effector function; however, CD4+ T cells are crucial in the proper development of these long-lasting effector CD8+ T cells. In this review, we summarize what is known about CD4+ T cells in chronic HBV infection and discuss the importance and opportunities of including CD4+ T cells in T cell-directed immunotherapeutic strategies to cure chronic HBV.",

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