Cellular Origin(s) of Congenital Diaphragmatic Hernia

Gabriëla G. Edel, Gerben Schaaf, Rene M.H. Wijnen, Dick Tibboel, Gabrielle Kardon, Robbert J. Rottier*

*Corresponding author for this work

Research output: Contribution to journalReview articleAcademicpeer-review

9 Citations (Scopus)
22 Downloads (Pure)


Congenital diaphragmatic hernia (CDH) is a structural birth defect characterized by a diaphragmatic defect, lung hypoplasia and structural vascular defects. In spite of recent developments, the pathogenesis of CDH is still poorly understood. CDH is a complex congenital disorder with multifactorial etiology consisting of genetic, cellular and mechanical factors. This review explores the cellular origin of CDH pathogenesis in the diaphragm and lungs and describes recent developments in basic and translational CDH research.

Original languageEnglish
Article number804496
JournalFrontiers in Pediatrics
Publication statusPublished - 30 Nov 2021

Bibliographical note

Funding Information:
This work was supported by the Sophia Foundation for Scientific Research [Grant Nos. S17-20 (GE and RR)].

Publisher Copyright:
Copyright © 2021 Edel, Schaaf, Wijnen, Tibboel, Kardon and Rottier.


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