Congenital diaphragmatic hernia (CDH) is a structural birth defect characterized by a diaphragmatic defect, lung hypoplasia and structural vascular defects. In spite of recent developments, the pathogenesis of CDH is still poorly understood. CDH is a complex congenital disorder with multifactorial etiology consisting of genetic, cellular and mechanical factors. This review explores the cellular origin of CDH pathogenesis in the diaphragm and lungs and describes recent developments in basic and translational CDH research.
|Journal||Frontiers in Pediatrics|
|Publication status||Published - 30 Nov 2021|
Bibliographical noteFunding Information:
This work was supported by the Sophia Foundation for Scientific Research [Grant Nos. S17-20 (GE and RR)].
Copyright © 2021 Edel, Schaaf, Wijnen, Tibboel, Kardon and Rottier.