Cellular Origin(s) of Congenital Diaphragmatic Hernia

Gabriëla G. Edel; Gerben Schaaf; Rene M.H. Wijnen; Dick Tibboel; Gabrielle Kardon; Robbert J. Rottier

doi:10.3389/fped.2021.804496

Cellular Origin(s) of Congenital Diaphragmatic Hernia

Gabriëla G. Edel, Gerben Schaaf, Rene M.H. Wijnen, Dick Tibboel, Gabrielle Kardon, Robbert J. Rottier^*

^*Corresponding author for this work

Research output: Contribution to journal › Review article › Academic › peer-review

4 Citations (Scopus)

7 Downloads (Pure)

Abstract

Congenital diaphragmatic hernia (CDH) is a structural birth defect characterized by a diaphragmatic defect, lung hypoplasia and structural vascular defects. In spite of recent developments, the pathogenesis of CDH is still poorly understood. CDH is a complex congenital disorder with multifactorial etiology consisting of genetic, cellular and mechanical factors. This review explores the cellular origin of CDH pathogenesis in the diaphragm and lungs and describes recent developments in basic and translational CDH research.

Original language	English
Article number	804496
Journal	Frontiers in Pediatrics
Volume	9
DOIs	https://doi.org/10.3389/fped.2021.804496
Publication status	Published - 30 Nov 2021

Bibliographical note

Funding Information:
This work was supported by the Sophia Foundation for Scientific Research [Grant Nos. S17-20 (GE and RR)].

Publisher Copyright:
Copyright © 2021 Edel, Schaaf, Wijnen, Tibboel, Kardon and Rottier.

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10.3389/fped.2021.804496Licence: CC BY

Cellular Origin(s) of Congenital Diaphragmatic HerniaFinal published version, 176 KBLicence: CC BY

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title = "Cellular Origin(s) of Congenital Diaphragmatic Hernia",

abstract = "Congenital diaphragmatic hernia (CDH) is a structural birth defect characterized by a diaphragmatic defect, lung hypoplasia and structural vascular defects. In spite of recent developments, the pathogenesis of CDH is still poorly understood. CDH is a complex congenital disorder with multifactorial etiology consisting of genetic, cellular and mechanical factors. This review explores the cellular origin of CDH pathogenesis in the diaphragm and lungs and describes recent developments in basic and translational CDH research.",

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AU - Edel, Gabriëla G.

AU - Schaaf, Gerben

AU - Wijnen, Rene M.H.

AU - Tibboel, Dick

AU - Kardon, Gabrielle

AU - Rottier, Robbert J.

N1 - Funding Information: This work was supported by the Sophia Foundation for Scientific Research [Grant Nos. S17-20 (GE and RR)]. Publisher Copyright: Copyright © 2021 Edel, Schaaf, Wijnen, Tibboel, Kardon and Rottier.

PY - 2021/11/30

Y1 - 2021/11/30

N2 - Congenital diaphragmatic hernia (CDH) is a structural birth defect characterized by a diaphragmatic defect, lung hypoplasia and structural vascular defects. In spite of recent developments, the pathogenesis of CDH is still poorly understood. CDH is a complex congenital disorder with multifactorial etiology consisting of genetic, cellular and mechanical factors. This review explores the cellular origin of CDH pathogenesis in the diaphragm and lungs and describes recent developments in basic and translational CDH research.

AB - Congenital diaphragmatic hernia (CDH) is a structural birth defect characterized by a diaphragmatic defect, lung hypoplasia and structural vascular defects. In spite of recent developments, the pathogenesis of CDH is still poorly understood. CDH is a complex congenital disorder with multifactorial etiology consisting of genetic, cellular and mechanical factors. This review explores the cellular origin of CDH pathogenesis in the diaphragm and lungs and describes recent developments in basic and translational CDH research.

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U2 - 10.3389/fped.2021.804496

DO - 10.3389/fped.2021.804496

M3 - Review article

AN - SCOPUS:85121272895

SN - 2296-2360

VL - 9

JO - Frontiers in Pediatrics

JF - Frontiers in Pediatrics

M1 - 804496

ER -

Cellular Origin(s) of Congenital Diaphragmatic Hernia

Abstract

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