Cellular therapies in organ transplantation

Martin J. Hoogduijn*, Fadi Issa, Federica Casiraghi, Marlies E. J. Reinders

*Corresponding author for this work

Research output: Contribution to journalReview articleAcademicpeer-review

6 Citations (Scopus)
1 Downloads (Pure)

Abstract

Cellular therapy is a promising tool for improving the outcome of organ
transplantation. Various cell types with different immunoregulatory and
regenerative properties may find application for specific transplant rejection or injury-related indications. The current era is crucial for the development of cellular therapies. Preclinical models have demonstrated the
feasibility of efficacious cell therapy in transplantation, early clinical trials
have shown safety of several of these therapies, and the first steps towards
efficacy studies in humans have been made. In this review, we address the
current state of the art of cellular therapies in clinical transplantation and
discuss monitoring tools and endpoints for these studies.
Original languageEnglish
Pages (from-to)233-244
Number of pages12
JournalTransplant International
Volume34
Issue number2
DOIs
Publication statusPublished - 15 Jan 2021

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