Abstract
Cellular therapy is a promising tool for improving the outcome of organ
transplantation. Various cell types with different immunoregulatory and
regenerative properties may find application for specific transplant rejection or injury-related indications. The current era is crucial for the development of cellular therapies. Preclinical models have demonstrated the
feasibility of efficacious cell therapy in transplantation, early clinical trials
have shown safety of several of these therapies, and the first steps towards
efficacy studies in humans have been made. In this review, we address the
current state of the art of cellular therapies in clinical transplantation and
discuss monitoring tools and endpoints for these studies.
transplantation. Various cell types with different immunoregulatory and
regenerative properties may find application for specific transplant rejection or injury-related indications. The current era is crucial for the development of cellular therapies. Preclinical models have demonstrated the
feasibility of efficacious cell therapy in transplantation, early clinical trials
have shown safety of several of these therapies, and the first steps towards
efficacy studies in humans have been made. In this review, we address the
current state of the art of cellular therapies in clinical transplantation and
discuss monitoring tools and endpoints for these studies.
| Original language | English |
|---|---|
| Pages (from-to) | 233-244 |
| Number of pages | 12 |
| Journal | Transplant International |
| Volume | 34 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - Feb 2021 |
Bibliographical note
Publisher Copyright:© 2020 The Authors. Transplant International published by John Wiley & Sons Ltd on behalf of Steunstichting ESOT
Research programs
- EMC OR-01