Cerebellar Cathodal Transcranial Direct Stimulation and Performance on a Verb Generation Task: A Replication Study

K. Spielmann*, R. van der Vliet, W. M. E. van de Sandt-Koenderman, M. A. Frens, G. M. Ribbers, R. W. Selles, S. van Vugt, J. N. van der Geest, P. Holland

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

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Abstract

The role of the cerebellum in cognitive processing is increasingly recognized but still poorly understood. A recent study in this field applied cerebellar Transcranial Direct Current Stimulation (c-tDCS) to the right cerebellum to investigate the role of prefrontal-cerebellar loops in language aspects of cognition. Results showed that the improvement in participants' verbal response times on a verb generation task was facilitated immediately after cathodal c-tDCS, compared to anodal or sham c-tDCS. The primary aim of the present study is to replicate these findings and additionally to investigate possible longer term effects. A crossover within-subject design was used, comparing cathodal and sham c-tDCS. The experiment consisted of two visits with an interval of one week. Our results show no direct contribution of cathodal c-tDCS over the cerebellum to language task performance. However, one week later, the group receiving cathodal c-tDCS in the first visit show less improvement and increased variability in their verbal response times during the second visit, compared to the group receiving sham c-tDCS in the first visit. These findings suggest a potential negative effect of c-tDCS and warrant further investigation into long term effects of c-tDCS before undertaking clinical studies with poststroke patients with aphasia.
Original languageEnglish
Article number1254615
Number of pages12
JournalNeural Plasticity
Volume2017
DOIs
Publication statusPublished - 2017

Bibliographical note

Funding:
This work was supported by ZonMW (Project no. 10-10400-
98-008), Stichting Coolsingel, C7. Marie Curie Initial Training Initiative and a TC2N InterReg Grant and a Kreitman
Postdoctoral fellowship.

Research programs

  • EMC NIHES-01-50-01-A

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