Cerebellar degeneration associated with mGluR1 autoantibodies as a paraneoplastic manifestation of prostate adenocarcinoma

R Iorio, V Damato, M Mirabella, MG Vita, Esther Hulsenboom, D Plantone, A Bizzarro, A Del Grande, Peter Sillevis Smitt

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Subacute cerebellar degeneration associated with metabotropic glutamate receptor type 1 (mGluR1) autoantibodies is an uncommon syndrome known to be part of the spectrum of paraneoplastic cerebellar degenerations associated with neuronal autoantibodies. We describe a patient with prostate adenocarcinoma who developed a subacute cerebellar ataxia. Autoantibodies specific to mGluR1 were detected in patient's serum and cerebrospinal fluid (CSF). Immunohistochemistry analyses of patient's prostate adenocarcinoma revealed abundant mGluR1 expression in luminal acinar epithelial cells and binding of patient's IgGs to tumoral mGluR1. These findings suggest that cerebellar degeneration associated with mGluR1 antibodies can be a paraneoplastic accompaniment of prostate adenocarcinoma. (C) 2013 Elsevier B.V. All rights reserved.
Original languageUndefined/Unknown
Pages (from-to)155-158
Number of pages4
JournalJournal of Neuroimmunology
Issue number1-2
Publication statusPublished - 2013

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