Cerebellum-dependent associative learning is not impaired in a mouse model of neurofibromatosis type 1

M. J. Ottenhoff, S. Dijkhuizen, A. C.H. Ypelaar, N. L. de Oude, S. K.E. Koekkoek, S. S.H. Wang, C. I. De Zeeuw, Y. Elgersma, H. J. Boele*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review


Individuals with Neurofibromatosis type 1 (NF1) experience a high degree of motor problems. The cerebellum plays a pivotal role in motor functioning and the NF1 gene is highly expressed in cerebellar Purkinje cells. However, it is not well understood to what extent NF1 affects cerebellar functioning and how this relates to NF1 motor functioning. Therefore, we subjected global Nf1+/− mice to a cerebellum-dependent associative learning task, called Pavlovian eyeblink conditioning. Additionally, we assessed general motor function and muscle strength in Nf1+/− mice. To our surprise, we found that Nf1+/− mice showed a moderately increased learning rate of conditioned eyeblink responses, as well as improved accuracy in the adaptive timing of the eyeblink responses. Locomotion, balance, general motor function, and muscle strength were not affected in Nf1+/− mice. Together, our results support the view that cerebellar function in Nf1+/− mice is unimpaired.

Original languageEnglish
Article number19041
JournalScientific Reports
Issue number1
Publication statusPublished - 9 Nov 2022

Bibliographical note

Tis work was fnancially supported by the Netherlands Organization for Scientifc Research—Veni ZonMW
91618112 (HJB), Erasmus MC Fellowship 106958 (HJB), New Jersey Autism Center for Excellence Fellowship
CAUT20AFP006 (HJB), the Netherlands Organization for Scientifc Research (NWO-ALW 824.02.001; CIDZ),
the Netherlands Organization for Medical Sciences (ZonMW 91120067; CIDZ), Medical Neuro-Delta (MD
01092019-31082023; CIDZ), INTENSE LSH-NWO (TTW/00798883; CIDZ), ERC-adv (GA-294775 CIDZ) and
ERC-POC (nrs. 737619 and 768914; CIDZ), the Albinism Vriendenfonds NIN (CIDZ), and National Institutes
of Health grants R01 NS045193 and R01 MH115750 (SSHW).

Publisher Copyright: © 2022, The Author(s).


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