TY - JOUR
T1 - Changes in Migraine Symptoms after Ischemic Stroke
T2 - A Cohort Study
AU - van der Weerd, Nelleke
AU - Pelzer, Nadine
AU - Egberts, Emma
AU - Mertens, Marit
AU - Bakker, Willemijn
AU - Linstra, Katie M.
AU - van den Maagdenberg, Arn M. J. M.
AU - van Zwet, Erik W.
AU - MaassenVanDenBrink, Antoinette
AU - Terwindt, Gisela M.
AU - Wermer, Marieke J. H.
PY - 2024/5/23
Y1 - 2024/5/23
N2 - Introduction: Migraine symptoms are postulated to improve post-stroke. We aimed to determine post-stroke changes in patients with active migraine pre-stroke and explored the relation with stroke location and stroke-preventive medication use. Methods: Patients with active migraine who had an ischemic stroke were retrieved from three research-cohorts between 2014 and 2021. By an interview, we retrospectively investigated fi rst-year post-stroke changes for those ischemic stroke patients that suffered from migraine pre-stroke. Associations between change in migraine frequency/intensity/aura (decrease, no change, increase), stroke location (posterior location vs. other), and use of secondary stroke preventive medication were assessed by ordinal regression with adjustment for confounders. Results: We included 78 patients (mean age 48 years, 86% women, 47% with aura). Change in migraine symptomatology was reported by 63 (81%) patients; 51 (81%) noticed a decrease in attack frequency (27 no attacks) and 12 (19%) an increase. Pain intensity change was reported by 18 (35%) patients (50% increase, 50% decrease). Aura symptomatology improved in 4 (11%). Reduced attack frequency was not related to posterior stroke (OR = 1.5, 95% CI: 0.6-3.9), or preventive medication (antiplatelets OR = 1.0, 95% CI: 0.2-3.7; coumarin OR = 2.7, 95% CI: 0.4-20.6). Conclusions: Most patients with active pre-stroke migraine experience improvement of their symptoms in the fi rst year after ischemic stroke. This change does not seem to be related to secondary stroke preventive medication or posterior stroke location. (c) 2024 The Author(s). Published by S. Karger AG, Basel
AB - Introduction: Migraine symptoms are postulated to improve post-stroke. We aimed to determine post-stroke changes in patients with active migraine pre-stroke and explored the relation with stroke location and stroke-preventive medication use. Methods: Patients with active migraine who had an ischemic stroke were retrieved from three research-cohorts between 2014 and 2021. By an interview, we retrospectively investigated fi rst-year post-stroke changes for those ischemic stroke patients that suffered from migraine pre-stroke. Associations between change in migraine frequency/intensity/aura (decrease, no change, increase), stroke location (posterior location vs. other), and use of secondary stroke preventive medication were assessed by ordinal regression with adjustment for confounders. Results: We included 78 patients (mean age 48 years, 86% women, 47% with aura). Change in migraine symptomatology was reported by 63 (81%) patients; 51 (81%) noticed a decrease in attack frequency (27 no attacks) and 12 (19%) an increase. Pain intensity change was reported by 18 (35%) patients (50% increase, 50% decrease). Aura symptomatology improved in 4 (11%). Reduced attack frequency was not related to posterior stroke (OR = 1.5, 95% CI: 0.6-3.9), or preventive medication (antiplatelets OR = 1.0, 95% CI: 0.2-3.7; coumarin OR = 2.7, 95% CI: 0.4-20.6). Conclusions: Most patients with active pre-stroke migraine experience improvement of their symptoms in the fi rst year after ischemic stroke. This change does not seem to be related to secondary stroke preventive medication or posterior stroke location. (c) 2024 The Author(s). Published by S. Karger AG, Basel
UR - https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=eur_pure&SrcAuth=WosAPI&KeyUT=WOS:001356221200001&DestLinkType=FullRecord&DestApp=WOS_CPL
U2 - 10.1159/000539421
DO - 10.1159/000539421
M3 - Article
C2 - 38781942
SN - 1015-9770
JO - Cerebrovascular Diseases
JF - Cerebrovascular Diseases
ER -