Changes in Oxygenation Levels Precede Changes in Amplitude of the EEG in Premature Infants

A Caicedo; L Thewissen; A Smits; G Naulaers; K Allegaert; S Van Huffel

doi:10.1007/978-3-319-38810-6_19

Changes in Oxygenation Levels Precede Changes in Amplitude of the EEG in Premature Infants

A Caicedo^*, L Thewissen, A Smits, G Naulaers, K Allegaert, S Van Huffel

^*Corresponding author for this work

Pharmacy

Research output: Chapter/Conference proceeding › Conference proceeding › Academic › peer-review

10 Citations (Scopus)

Abstract

Brain function is supported by an appropriate balance between the metabolic demand and the supply of nutrients and oxygen. However, the physiological principles behind the regulation of brain metabolism and demand in premature infants are unknown. Some studies found that changes in hemodynamic variables in this population precede changes in EEG activity; however, these studies only used descriptive statistics. This paper describes the relationship between changes in cerebral oxygenation, assessed by means of near-infrared spectroscopy (NIRS), and changes in EEG, using mathematical methods taken from information dynamics. In a cohort of 35 neonates subjected to sedation by propofol, we quantified the direction of information transfer between brain oxygenation and EEG. The results obtained indicate that, as reported in other studies, changes in NIRS are likely to precede changes in EEG activity.

Original language	English
Title of host publication	Oxygen Transport To Tissue Xxxviii
Editors	Q Luo, LZ Li, DK Harrison, H Shi, DF Bruley
Place of Publication	978-3-319-38808-3
Pages	143-149
Number of pages	7
Volume	923
Edition	1
ISBN (Electronic)	978-3-319-38810-6
DOIs	https://doi.org/10.1007/978-3-319-38810-6_19
Publication status	Published - 2016

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10.1007/978-3-319-38810-6_19

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title = "Changes in Oxygenation Levels Precede Changes in Amplitude of the EEG in Premature Infants",

abstract = "Brain function is supported by an appropriate balance between the metabolic demand and the supply of nutrients and oxygen. However, the physiological principles behind the regulation of brain metabolism and demand in premature infants are unknown. Some studies found that changes in hemodynamic variables in this population precede changes in EEG activity; however, these studies only used descriptive statistics. This paper describes the relationship between changes in cerebral oxygenation, assessed by means of near-infrared spectroscopy (NIRS), and changes in EEG, using mathematical methods taken from information dynamics. In a cohort of 35 neonates subjected to sedation by propofol, we quantified the direction of information transfer between brain oxygenation and EEG. The results obtained indicate that, as reported in other studies, changes in NIRS are likely to precede changes in EEG activity.",

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Changes in Oxygenation Levels Precede Changes in Amplitude of the EEG in Premature Infants. / Caicedo, A; Thewissen, L; Smits, A et al.
Oxygen Transport To Tissue Xxxviii. ed. / Q Luo; LZ Li; DK Harrison; H Shi; DF Bruley. Vol. 923 1. ed. 978-3-319-38808-3, 2016. p. 143-149.

Research output: Chapter/Conference proceeding › Conference proceeding › Academic › peer-review

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AU - Allegaert, K

AU - Van Huffel, S

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Changes in Oxygenation Levels Precede Changes in Amplitude of the EEG in Premature Infants

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