Characteristics and Outcome of Pediatric Non-Hodgkin Lymphoma Patients With Ovarian Infiltration at Presentation

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Abstract

BackgroundOvarian infiltration in pediatric non-Hodgkin lymphoma (NHL) at presentation is rare and information on outcome is scarce and mainly based on case reports and small series. ProcedureEvaluation of clinical characteristics and outcome of ovarian infiltrated pediatric NHL cases of a single center, and an extensive review of the all cases reported so far in literature. ResultsAt presentation, 6/60 female NHL cases of our center had ovarian infiltration, and combining these cases with earlier case reports, a total of 42 cases were identified. Median age at presentation was 10.9 years (range 0-18), and all but one had a B-cell immunophenotype, with 32/42 cases being classified as Burkitt. Bilateral involvement was reported in 26/41 cases, of which 22 were bilaterally ovariectomized as first treatment. All cases were treated with chemotherapy. Relapses were repor ConclusionsWe conclude that in case of ovarian tumors with negative markers, NHL should be considered in order to avoid unnecessary surgery. Pediatr Blood Cancer 2013;60:2054-2059. (c) 2013 Wiley Periodicals, Inc.
Original languageUndefined/Unknown
Pages (from-to)2054-2059
Number of pages6
JournalPediatric Blood & Cancer
Volume60
Issue number12
DOIs
Publication statusPublished - 2013

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