Characterization of a novel human cell-cycle-regulated homologue of Drosophila dlg1

Sahar Bassal, Nobuo Nomura, Deon Venter, Karl Brand, Michael J. McKay, Peter J. Van der Spek*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

31 Citations (Scopus)

Abstract

Cell cycle defects have been associated with the process of carcinogenesis in many studies. Here we report the cloning and analysis of the novel gene KIAA0008 (GenBank acc. no. D13633). Chromosomal localization experiments assigned the gene to chromosome 14q22-q23. The mRNA transcript was found to be cell cycle regulated, expressed at S-phase, and maintained at both G2- and M-phases. In situ hybridization showed expression in proliferating colon and breast (tumor) tissues. Structurally, KIAA0008 shares homology with the Drosophila melanogaster discs large-1 (dlg1) tumor suppressor gene and membrane-associated guanylate kinase protein family members. The potential involvement of KIAA0008 in cell proliferation is discussed, along with its sequence identity and tissue distribution.

Original languageEnglish
Pages (from-to)5-7
Number of pages3
JournalGenomics
Volume77
Issue number1-2
DOIs
Publication statusPublished - Sept 2001
Externally publishedYes

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