Characterization of the hemagglutinin and neuraminidase genes of recent influenza virus isolates from different avian species in Thailand

J. Keawcharoen; A. Amonsin; K. Oraveerakul; S. Wattanodorn; T. Papravasit; S. Karnda; K. Lekakul; R. Pattanarangsan; S. Noppornpanth; R. A.M. Fouchier; A. D.M.E. Osterhaus; S. Payungporn; A. Theamboonlers; Y. Poovorawan

Characterization of the hemagglutinin and neuraminidase genes of recent influenza virus isolates from different avian species in Thailand

J. Keawcharoen
, A. Amonsin
, K. Oraveerakul
, S. Wattanodorn
, T. Papravasit
, S. Karnda
, K. Lekakul
, R. Pattanarangsan
, S. Noppornpanth
, R. A.M. Fouchier
, A. D.M.E. Osterhaus
, S. Payungporn
, A. Theamboonlers
, Y. Poovorawan^*

^*Corresponding author for this work

Virology

Research output: Contribution to journal › Article › Academic › peer-review

13 Citations (Scopus)

Abstract

The hemagglutinin (HA) and neuraminidase (NA) genes of eight influenza A virus (H5N1) isolates obtained from various avian species in Thailand in 2003-2004 have been characterized in comparison with the Thai isolate A/Chicken/Nakorn-Pathom/Thailand/CU-K2/04(H5N1). Phylogenetic analyses of both genes revealed that all the eight avian isolates were closely related to the A/Chicken/Nakorn-Pathom/Thailand/CU-K2/ 04(H5N1). The amino acid sequence of the HA cleavage site revealed a common characteristic of a highly pathogenic virus strain. Moreover, a deletion of 20 amino acids in the NA stalk region was detected in all Thai isolates in contrast to the H5N1 strain that had caused outbreaks in eastern Asia in 1996-1997 and 2000-2001.

Original language	English
Pages (from-to)	277-280
Number of pages	4
Journal	Acta Virologica
Volume	49
Issue number	4
Publication status	Published - 2005

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Keawcharoen, J., Amonsin, A., Oraveerakul, K., Wattanodorn, S., Papravasit, T., Karnda, S., Lekakul, K., Pattanarangsan, R., Noppornpanth, S., Fouchier, R. A. M., Osterhaus, A. D. M. E., Payungporn, S., Theamboonlers, A., & Poovorawan, Y. (2005). Characterization of the hemagglutinin and neuraminidase genes of recent influenza virus isolates from different avian species in Thailand. Acta Virologica, 49(4), 277-280.

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title = "Characterization of the hemagglutinin and neuraminidase genes of recent influenza virus isolates from different avian species in Thailand",

abstract = "The hemagglutinin (HA) and neuraminidase (NA) genes of eight influenza A virus (H5N1) isolates obtained from various avian species in Thailand in 2003-2004 have been characterized in comparison with the Thai isolate A/Chicken/Nakorn-Pathom/Thailand/CU-K2/04(H5N1). Phylogenetic analyses of both genes revealed that all the eight avian isolates were closely related to the A/Chicken/Nakorn-Pathom/Thailand/CU-K2/ 04(H5N1). The amino acid sequence of the HA cleavage site revealed a common characteristic of a highly pathogenic virus strain. Moreover, a deletion of 20 amino acids in the NA stalk region was detected in all Thai isolates in contrast to the H5N1 strain that had caused outbreaks in eastern Asia in 1996-1997 and 2000-2001.",

author = "J. Keawcharoen and A. Amonsin and K. Oraveerakul and S. Wattanodorn and T. Papravasit and S. Karnda and K. Lekakul and R. Pattanarangsan and S. Noppornpanth and Fouchier, \{R. A.M.\} and Osterhaus, \{A. D.M.E.\} and S. Payungporn and A. Theamboonlers and Y. Poovorawan",

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Keawcharoen, J, Amonsin, A, Oraveerakul, K, Wattanodorn, S, Papravasit, T, Karnda, S, Lekakul, K, Pattanarangsan, R, Noppornpanth, S, Fouchier, RAM, Osterhaus, ADME, Payungporn, S, Theamboonlers, A & Poovorawan, Y 2005, 'Characterization of the hemagglutinin and neuraminidase genes of recent influenza virus isolates from different avian species in Thailand', Acta Virologica, vol. 49, no. 4, pp. 277-280.

TY - JOUR

T1 - Characterization of the hemagglutinin and neuraminidase genes of recent influenza virus isolates from different avian species in Thailand

AU - Keawcharoen, J.

AU - Amonsin, A.

AU - Oraveerakul, K.

AU - Wattanodorn, S.

AU - Papravasit, T.

AU - Karnda, S.

AU - Lekakul, K.

AU - Pattanarangsan, R.

AU - Noppornpanth, S.

AU - Fouchier, R. A.M.

AU - Osterhaus, A. D.M.E.

AU - Payungporn, S.

AU - Theamboonlers, A.

AU - Poovorawan, Y.

PY - 2005

Y1 - 2005

N2 - The hemagglutinin (HA) and neuraminidase (NA) genes of eight influenza A virus (H5N1) isolates obtained from various avian species in Thailand in 2003-2004 have been characterized in comparison with the Thai isolate A/Chicken/Nakorn-Pathom/Thailand/CU-K2/04(H5N1). Phylogenetic analyses of both genes revealed that all the eight avian isolates were closely related to the A/Chicken/Nakorn-Pathom/Thailand/CU-K2/ 04(H5N1). The amino acid sequence of the HA cleavage site revealed a common characteristic of a highly pathogenic virus strain. Moreover, a deletion of 20 amino acids in the NA stalk region was detected in all Thai isolates in contrast to the H5N1 strain that had caused outbreaks in eastern Asia in 1996-1997 and 2000-2001.

AB - The hemagglutinin (HA) and neuraminidase (NA) genes of eight influenza A virus (H5N1) isolates obtained from various avian species in Thailand in 2003-2004 have been characterized in comparison with the Thai isolate A/Chicken/Nakorn-Pathom/Thailand/CU-K2/04(H5N1). Phylogenetic analyses of both genes revealed that all the eight avian isolates were closely related to the A/Chicken/Nakorn-Pathom/Thailand/CU-K2/ 04(H5N1). The amino acid sequence of the HA cleavage site revealed a common characteristic of a highly pathogenic virus strain. Moreover, a deletion of 20 amino acids in the NA stalk region was detected in all Thai isolates in contrast to the H5N1 strain that had caused outbreaks in eastern Asia in 1996-1997 and 2000-2001.

UR - https://www.scopus.com/pages/publications/33645982594

UR - https://www.researchgate.net/publication/7368653_Characterization_of_the_hemagglutinin_and_neuraminidase_genes_of_recent_influenza_virus_isolates_from_different_avian_species_in_Thailand

M3 - Article

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AN - SCOPUS:33645982594

SN - 0001-723X

VL - 49

SP - 277

EP - 280

JO - Acta Virologica

JF - Acta Virologica

IS - 4

ER -

Characterization of the hemagglutinin and neuraminidase genes of recent influenza virus isolates from different avian species in Thailand

Abstract

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