Characterization of the Human CD8(+) T Cell Response following Infection with 2009 Pandemic Influenza H1N1 Virus

Marine Hillaire, Stella Trierum, Rogier Bodewes, Carel Baalen, RS van Binnendijk, Marion Koopmans, Ron Fouchier, Ab Osterhaus, Guus Rimmelzwaan

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The 2009 H1N1 influenza pandemic provided an opportunity to study human virus-specific T cell responses after infection with a novel influenza virus against which limited humoral immunity existed in the population. Here we describe the magnitude, kinetics, and nature of the virus-specific T cell response using intracellular gamma interferon (IFN-gamma) staining and fluorochrome-labeled major histocompatibility complex (MHC) class I-peptide complexes. We demonstrate that influenza virus-infected patients develop recall T cell responses that peak within 1 week postinfection and that contract rapidly. In particular, effector cell frequencies declined rapidly postinfection in favor of relatively larger proportions of central memory cells.
Original languageUndefined/Unknown
Pages (from-to)12057-12061
Number of pages5
JournalJournal of Virology
Issue number22
Publication statusPublished - 2011

Research programs

  • EMC MM-04-27-01

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