Abstract
The 2009 H1N1 influenza pandemic provided an opportunity to study human virus-specific T cell responses after infection with a novel influenza virus against which limited humoral immunity existed in the population. Here we describe the magnitude, kinetics, and nature of the virus-specific T cell response using intracellular gamma interferon (IFN-gamma) staining and fluorochrome-labeled major histocompatibility complex (MHC) class I-peptide complexes. We demonstrate that influenza virus-infected patients develop recall T cell responses that peak within 1 week postinfection and that contract rapidly. In particular, effector cell frequencies declined rapidly postinfection in favor of relatively larger proportions of central memory cells.
Original language | Undefined/Unknown |
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Pages (from-to) | 12057-12061 |
Number of pages | 5 |
Journal | Journal of Virology |
Volume | 85 |
Issue number | 22 |
DOIs | |
Publication status | Published - 2011 |
Research programs
- EMC MM-04-27-01