Characterization of the Human CD8(+) T Cell Response following Infection with 2009 Pandemic Influenza H1N1 Virus

Marine Hillaire, Stella Trierum, Rogier Bodewes, Carel Baalen, RS van Binnendijk, Marion Koopmans, Ron Fouchier, Ab Osterhaus, Guus Rimmelzwaan

Research output: Contribution to journalArticleAcademicpeer-review

44 Citations (Scopus)

Abstract

The 2009 H1N1 influenza pandemic provided an opportunity to study human virus-specific T cell responses after infection with a novel influenza virus against which limited humoral immunity existed in the population. Here we describe the magnitude, kinetics, and nature of the virus-specific T cell response using intracellular gamma interferon (IFN-gamma) staining and fluorochrome-labeled major histocompatibility complex (MHC) class I-peptide complexes. We demonstrate that influenza virus-infected patients develop recall T cell responses that peak within 1 week postinfection and that contract rapidly. In particular, effector cell frequencies declined rapidly postinfection in favor of relatively larger proportions of central memory cells.
Original languageUndefined/Unknown
Pages (from-to)12057-12061
Number of pages5
JournalJournal of Virology
Volume85
Issue number22
DOIs
Publication statusPublished - 2011

Research programs

  • EMC MM-04-27-01

Cite this