Abstract
Protein crystals derived from innate immune cells have been synonymous with a Type-2 immune response in both mouse and man for over 150 years. Eosinophilic Galectin-10 (Charcot–Leyden) crystals in humans, and Ym1/Ym2 crystals in mice are frequently found in the context of parasitic infections, but also in diseases such as asthma and chronic rhinosinusitis. Despite their notable presence, these crystals are often overlooked as trivial markers of Type-2 inflammation. Here, we discuss the source, context, and role of protein crystallization. We focus on similarities observed between Galectin-10 and Ym1/2 crystals in driving immune responses; the subsequent benefit to the host during worm infection, and conversely the detrimental exacerbation of inflammation and mucus production during asthma.
| Original language | English |
|---|---|
| Pages (from-to) | 72-78 |
| Number of pages | 7 |
| Journal | Current Opinion in Immunology |
| Volume | 72 |
| DOIs | |
| Publication status | Published - Oct 2021 |
Bibliographical note
Funding Information:This work was funded by an Excellence of Science UHEAD consortium grant, an ERC Advanced grant and Concerted Research Action grant of the University of Ghent (to B.N.L.). H.A. was supported by a Vlaio grant (Vlaio-Baekeland HBC.2019.2632). U.S. was supported by a RESPIRE4 Marie Sklodowska-Curie research fellowship. I.H. was supported by an FWO PhD Fellowship (Aspirant FWO 11F0419N).Bart Lambrecht has received consultancy fees from Astra-Zeneca, Sanofi, GSK, Novartis, Oncoarendi and Argenx. These do not affect content of this article.
Funding Information:
This work was funded by an Excellence of Science UHEAD consortium grant, an ERC Advanced grant and Concerted Research Action grant of the University of Ghent (to B.N.L.). H.A. was supported by a Vlaio grant (Vlaio-Baekeland HBC.2019.2632). U.S. was supported by a RESPIRE4 Marie Sklodowska-Curie research fellowship. I.H. was supported by an FWO PhD Fellowship (Aspirant FWO 11F0419N ).
Publisher Copyright:
© 2021