Chest Computed Tomography Scores Are Predictive of Survival in Patients with Cystic Fibrosis Awaiting Lung Transplantation

Martine Loeve, Hop, Marleen de Bruijne, PTW Hal, P Robinson, ML Aitken, JD Dodd, H.A.W.M. Tiddens

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Abstract

Rationale: Up to one-third of patients with cystic fibrosis (CF) awaiting lung transplantation (LTX) die while waiting. Inclusion of computed tomography (CT) scores may improve survival prediction models such as the lung allocation score (LAS). Objectives: This study investigated the association between CT and survival in patients with CF screened for LTX. Methods: Clinical data and chest CTs of 411 patients with CF screened for LTX between 1990 and 2005 were collected from 17 centers. CTs were scored with the Severe Advanced Lung Disease (SALD) four-category scoring system, including the components infection/inflammation (INF), air trapping/hypoperfusion (AT), normal/hyperperfusion (NOR), and bulla/cysts (BUL). The volume of each component was computed using semiautomated software. Survival analysis included Kaplan-Meier curves and Cox regression Measurements and Main Results: Three hundred and sixty-six (186 males) of 411 patients entered the waiting list (median age, 23 yr; range, 5-58 yr). Subsequently, 67 of 366 (18%) died while waiting, 263 of 366 (72%) underwent LTX, and 36 of 366 (10%) were awaiting LTX at the census date. INF and LAS were significantly associated with waiting list mortality in univariate analyses. The multivariate Cox model including INF and LAS grouped in tertiles, and comparing tertiles 2 and 3 with tertile 1, Conclusions: CT score INF correlates with survival, and adds to the predictive value of LAS.
Original languageUndefined/Unknown
Pages (from-to)1096-1103
Number of pages8
JournalAmerican Journal of Respiratory and Critical Care Medicine
Volume185
Issue number10
DOIs
Publication statusPublished - 2012

Research programs

  • EMC MM-04-42-02
  • EMC NIHES-01-66-01
  • EMC NIHES-03-30-01
  • EMC NIHES-03-30-03
  • EMC OR-01-54-02

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