Chlamydia trachomatis infection of human mesothelial cells alters proinflammatory, procoagulant, and fibrinolytic responses

M van Westreenen, A Pronk, R J Diepersloot, P G de Groot, P Leguit

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Abstract

In this study we demonstrate the capability of Chlamydia trachomatis to infect cultured human mesothelial cell (MC) monolayers and to induce the production of the proinflammatory cytokines interleukin 1beta (IL-1beta) and IL-8. Seventy-two hours after initial infection, both the procoagulant activity of MC and the activity of the fibrinolytic inhibitor (plasminogen activator inhibitor 1) in the supernatants were enhanced. These findings support the hypothesis that provoked proinflammatory responses contribute to the development of complications after chlamydial infection.

Original languageEnglish
Pages (from-to)2352-5
Number of pages4
JournalInfection and Immunity
Volume66
Issue number5
DOIs
Publication statusPublished - 1 May 1998
Externally publishedYes

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