Chloride-sensitive signaling turns the potassium switch on

Ewout J. Hoorn; Jeroen H.F. de Baaij

doi:10.1016/j.kint.2022.08.023

Chloride-sensitive signaling turns the potassium switch on

Ewout J. Hoorn^*
, Jeroen H.F. de Baaij

^*Corresponding author for this work

Internal Medicine

Radboud Institute for Molecular Life Sciences - RIMLS

Research output: Contribution to journal › Comment/Letter to the editor › Academic › peer-review

1 Citation (Scopus)

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Abstract

The potassium switch refers to plasma potassium regulation of the sodium-chloride cotransporter (NCC), which controls distal sodium delivery and therefore potassium secretion. Low extracellular potassium activates NCC by relieving chloride inhibition of With-No-Lysine 4 (WNK4). A new mouse model carrying a chloride-insensitive WNK4 mutant still shows NCC activation on low potassium diet. These effects are mediated by WNK4 activation and kelch-like 3 (KLHL3) inhibition and reveal additional chloride-sensitive pathways for NCC activation.

Original language	English
Pages (from-to)	956-958
Number of pages	3
Journal	Kidney International
Volume	102
Issue number	5
DOIs	https://doi.org/10.1016/j.kint.2022.08.023
Publication status	Published - 1 Nov 2022

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10.1016/j.kint.2022.08.023

1-s2.0-S0085253822006998-mainFinal published version, 717 KBLicence: Article 25fa Dutch Copyright Act

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title = "Chloride-sensitive signaling turns the potassium switch on",

abstract = "The potassium switch refers to plasma potassium regulation of the sodium-chloride cotransporter (NCC), which controls distal sodium delivery and therefore potassium secretion. Low extracellular potassium activates NCC by relieving chloride inhibition of With-No-Lysine 4 (WNK4). A new mouse model carrying a chloride-insensitive WNK4 mutant still shows NCC activation on low potassium diet. These effects are mediated by WNK4 activation and kelch-like 3 (KLHL3) inhibition and reveal additional chloride-sensitive pathways for NCC activation.",

author = "Hoorn, \{Ewout J.\} and \{de Baaij\}, \{Jeroen H.F.\}",

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T1 - Chloride-sensitive signaling turns the potassium switch on

AU - Hoorn, Ewout J.

AU - de Baaij, Jeroen H.F.

PY - 2022/11/1

Y1 - 2022/11/1

N2 - The potassium switch refers to plasma potassium regulation of the sodium-chloride cotransporter (NCC), which controls distal sodium delivery and therefore potassium secretion. Low extracellular potassium activates NCC by relieving chloride inhibition of With-No-Lysine 4 (WNK4). A new mouse model carrying a chloride-insensitive WNK4 mutant still shows NCC activation on low potassium diet. These effects are mediated by WNK4 activation and kelch-like 3 (KLHL3) inhibition and reveal additional chloride-sensitive pathways for NCC activation.

AB - The potassium switch refers to plasma potassium regulation of the sodium-chloride cotransporter (NCC), which controls distal sodium delivery and therefore potassium secretion. Low extracellular potassium activates NCC by relieving chloride inhibition of With-No-Lysine 4 (WNK4). A new mouse model carrying a chloride-insensitive WNK4 mutant still shows NCC activation on low potassium diet. These effects are mediated by WNK4 activation and kelch-like 3 (KLHL3) inhibition and reveal additional chloride-sensitive pathways for NCC activation.

UR - https://www.scopus.com/pages/publications/85139722212

U2 - 10.1016/j.kint.2022.08.023

DO - 10.1016/j.kint.2022.08.023

M3 - Comment/Letter to the editor

C2 - 36272750

AN - SCOPUS:85139722212

SN - 0085-2538

VL - 102

SP - 956

EP - 958

JO - Kidney International

JF - Kidney International

IS - 5

ER -

Chloride-sensitive signaling turns the potassium switch on

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