Chloroquine for treatment of COVID-19 results in subtherapeutic exposure and prolonged QTc intervals

R. J. Brüggemann; D. J.A.R. Moes; K. P. van Rhee; N. E. van 't Veer; B. C.P. Koch; M. van Rossum; A. Vermeulen Windsant - van den Tweel; M. H.E. Reijers; R. R.J. van Kimmenade; J. C. Rahamat-Langedoen; T. C.D. Rettig; R. van Raalte; J. van Paassen; F. N. Polderman; P. D. van der Linden; T. Frenzel; Q. de Mast; D. M. Burger; J. Schouten; F. L. van de Veerdonk; P. Pickkers; R. ter Heine

doi:10.1016/j.ijantimicag.2021.106293

Chloroquine for treatment of COVID-19 results in subtherapeutic exposure and prolonged QTc intervals

R. J. Brüggemann, D. J.A.R. Moes, K. P. van Rhee, N. E. van 't Veer, B. C.P. Koch, M. van Rossum, A. Vermeulen Windsant - van den Tweel, M. H.E. Reijers, R. R.J. van Kimmenade, J. C. Rahamat-Langedoen, T. C.D. Rettig, R. van Raalte, J. van Paassen, F. N. Polderman, P. D. van der Linden, T. Frenzel, Q. de Mast, D. M. Burger, J. Schouten, F. L. van de VeerdonkP. Pickkers, R. ter Heine^*

^*Corresponding author for this work

Pharmacy

Research output: Contribution to journal › Article › Academic › peer-review

Original language	English
Article number	106293
Journal	International Journal of Antimicrobial Agents
Volume	57
Issue number	3
Early online date	27 Jan 2021
DOIs	https://doi.org/10.1016/j.ijantimicag.2021.106293
Publication status	Published - Mar 2021

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Chloroquine for treatment of COVID-19 results in subtherapeutic exposure and prolonged QTc intervalsFinal published version, 460 KBLicence: CC BY-NC-ND

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Brüggemann, R. J., Moes, D. J. A. R., van Rhee, K. P., van 't Veer, N. E., Koch, B. C. P., van Rossum, M., Windsant - van den Tweel, A. V., Reijers, M. H. E., van Kimmenade, R. R. J., Rahamat-Langedoen, J. C., Rettig, T. C. D., van Raalte, R., van Paassen, J., Polderman, F. N., van der Linden, P. D., Frenzel, T., de Mast, Q., Burger, D. M., Schouten, J., ... ter Heine, R. (2021). Chloroquine for treatment of COVID-19 results in subtherapeutic exposure and prolonged QTc intervals. International Journal of Antimicrobial Agents, 57(3), [106293]. https://doi.org/10.1016/j.ijantimicag.2021.106293

Brüggemann, R. J. ; Moes, D. J.A.R. ; van Rhee, K. P. ; van 't Veer, N. E. ; Koch, B. C.P. ; van Rossum, M. ; Windsant - van den Tweel, A. Vermeulen ; Reijers, M. H.E. ; van Kimmenade, R. R.J. ; Rahamat-Langedoen, J. C. ; Rettig, T. C.D. ; van Raalte, R. ; van Paassen, J. ; Polderman, F. N. ; van der Linden, P. D. ; Frenzel, T. ; de Mast, Q. ; Burger, D. M. ; Schouten, J. ; van de Veerdonk, F. L. ; Pickkers, P. ; ter Heine, R. / Chloroquine for treatment of COVID-19 results in subtherapeutic exposure and prolonged QTc intervals. In: International Journal of Antimicrobial Agents. 2021 ; Vol. 57, No. 3.

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title = "Chloroquine for treatment of COVID-19 results in subtherapeutic exposure and prolonged QTc intervals",

author = "Br{\"u}ggemann, {R. J.} and Moes, {D. J.A.R.} and {van Rhee}, {K. P.} and {van 't Veer}, {N. E.} and Koch, {B. C.P.} and {van Rossum}, M. and {Windsant - van den Tweel}, {A. Vermeulen} and Reijers, {M. H.E.} and {van Kimmenade}, {R. R.J.} and Rahamat-Langedoen, {J. C.} and Rettig, {T. C.D.} and {van Raalte}, R. and {van Paassen}, J. and Polderman, {F. N.} and {van der Linden}, {P. D.} and T. Frenzel and {de Mast}, Q. and Burger, {D. M.} and J. Schouten and {van de Veerdonk}, {F. L.} and P. Pickkers and {ter Heine}, R.",

year = "2021",

month = mar,

doi = "10.1016/j.ijantimicag.2021.106293",

language = "English",

volume = "57",

journal = "International Journal of Antimicrobial Agents",

issn = "0924-8579",

publisher = "Elsevier",

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Brüggemann, RJ, Moes, DJAR, van Rhee, KP, van 't Veer, NE, Koch, BCP, van Rossum, M, Windsant - van den Tweel, AV, Reijers, MHE, van Kimmenade, RRJ, Rahamat-Langedoen, JC, Rettig, TCD, van Raalte, R, van Paassen, J, Polderman, FN, van der Linden, PD, Frenzel, T, de Mast, Q, Burger, DM, Schouten, J, van de Veerdonk, FL, Pickkers, P & ter Heine, R 2021, 'Chloroquine for treatment of COVID-19 results in subtherapeutic exposure and prolonged QTc intervals', International Journal of Antimicrobial Agents, vol. 57, no. 3, 106293. https://doi.org/10.1016/j.ijantimicag.2021.106293

Chloroquine for treatment of COVID-19 results in subtherapeutic exposure and prolonged QTc intervals. / Brüggemann, R. J.; Moes, D. J.A.R.; van Rhee, K. P.; van 't Veer, N. E.; Koch, B. C.P.; van Rossum, M.; Windsant - van den Tweel, A. Vermeulen; Reijers, M. H.E.; van Kimmenade, R. R.J.; Rahamat-Langedoen, J. C.; Rettig, T. C.D.; van Raalte, R.; van Paassen, J.; Polderman, F. N.; van der Linden, P. D.; Frenzel, T.; de Mast, Q.; Burger, D. M.; Schouten, J.; van de Veerdonk, F. L.; Pickkers, P.; ter Heine, R.

In: International Journal of Antimicrobial Agents, Vol. 57, No. 3, 106293, 03.2021.

Research output: Contribution to journal › Article › Academic › peer-review

TY - JOUR

T1 - Chloroquine for treatment of COVID-19 results in subtherapeutic exposure and prolonged QTc intervals

AU - Brüggemann, R. J.

AU - Moes, D. J.A.R.

AU - van Rhee, K. P.

AU - van 't Veer, N. E.

AU - Koch, B. C.P.

AU - van Rossum, M.

AU - Windsant - van den Tweel, A. Vermeulen

AU - Reijers, M. H.E.

AU - van Kimmenade, R. R.J.

AU - Rahamat-Langedoen, J. C.

AU - Rettig, T. C.D.

AU - van Raalte, R.

AU - van Paassen, J.

AU - Polderman, F. N.

AU - van der Linden, P. D.

AU - Frenzel, T.

AU - de Mast, Q.

AU - Burger, D. M.

AU - Schouten, J.

AU - van de Veerdonk, F. L.

AU - Pickkers, P.

AU - ter Heine, R.

PY - 2021/3

Y1 - 2021/3

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U2 - 10.1016/j.ijantimicag.2021.106293

DO - 10.1016/j.ijantimicag.2021.106293

M3 - Article

C2 - 33515687

AN - SCOPUS:85100714810

VL - 57

JO - International Journal of Antimicrobial Agents

JF - International Journal of Antimicrobial Agents

SN - 0924-8579

IS - 3

M1 - 106293

ER -

Chloroquine for treatment of COVID-19 results in subtherapeutic exposure and prolonged QTc intervals

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