Chromatin Conformation in Development and Disease

Ilias Boltsis, Frank Grosveld, Guillaume Giraud*, Petros Kolovos

*Corresponding author for this work

Research output: Contribution to journalReview articleProfessionalpeer-review

21 Citations (Scopus)


Chromatin domains and loops are important elements of chromatin structure and dynamics, but much remains to be learned about their exact biological role and nature. Topological associated domains and functional loops are key to gene expression and hold the answer to many questions regarding developmental decisions and diseases. Here, we discuss new findings, which have linked chromatin conformation with development, differentiation and diseases and hypothesized on various models while integrating all recent findings on how chromatin architecture affects gene expression during development, evolution and disease.

Original languageEnglish
Article number723859
JournalFrontiers in Cell and Developmental Biology
Publication statusPublished - 4 Aug 2021

Bibliographical note

Funding Information:
Funding. IB, FG, and GG were supported by BluePrint EU Integrated Project, the SyBOSS EU consortium (no. 050040212), the Netherlands Institute for Regenerative Medicine (NIRM), a MEC Booster grant from the Netherlands Genomics Institute (MEC Booster grant), and a European People Marie Curie Actions Program, Marie Curie European Reintegration Grant (ERG; FP7-PEOPLE-2010-RG). GG is also supported by ANRS Maladies Infectieuses Emergentes (ECTZ161842).

Publisher Copyright:
© Copyright © 2021 Boltsis, Grosveld, Giraud and Kolovos.


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