Abstract
Autosomal dominant polycystic kidney disease (ADPKD) is a genetically heterogeneous disorder. A gene defect located on the short arm of chromosome 16 is responsible for the disease in roughly 86% of affected European families. Using highly polymorphic microsatellite DNA markers, we have assigned a second gene for ADPKD to chromosome 4. In eight families with clear evidence against linkage to chromosome 16 markers, linkage analysis with the markers D4S231 and D4S423, demonstrated a multipoint lod score of 22.42.
Original language | English |
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Pages (from-to) | 359-362 |
Number of pages | 4 |
Journal | Nature Genetics |
Volume | 5 |
Issue number | 4 |
DOIs | |
Publication status | Published - Dec 1993 |