Chronic hepatitis E: Advancing research and patient care

Zhongren Ma, Robert A de Man, Nassim Kamar, Qiuwei Pan*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

45 Citations (Scopus)
130 Downloads (Pure)


The hepatitis E virus (HEV) was initially thought to exclusively cause acute hepatitis. However, the first diagnosis of chronic hepatitis E in transplant recipients in 2008 profoundly changed our understanding of this pathogen. We have now begun to understand that specific HEV genotypes can cause chronic infection in certain immunocompromised populations. Over the past decade, dedicated clinical and experimental research has substantiated knowledge on the epidemiology, transmission routes, pathophysiological mechanisms, diagnosis, clinical features and treatment of chronic HEV infection. Nevertheless, many gaps and major challenges remain, particularly regarding the translation of knowledge into disease prevention and improvement of clinical outcomes. This article aims to highlight the latest developments in the understanding and management of chronic hepatitis E. More importantly, we attempt to identify major knowledge gaps and discuss strategies for further advancing both research and patient care.

Original languageEnglish
Pages (from-to)1109-1123
Number of pages15
JournalJournal of Hepatology
Issue number4
Early online date21 May 2022
Publication statusPublished - Oct 2022

Bibliographical note

Funding Information:
Q.P. is supported by a VIDI grant (No. 91719300 ) from the Netherlands Organisation for Scientific Research (NWO) and a Young Investigator Grant ( 10140 ) from the Dutch Cancer Society .

Publisher Copyright:
© 2022 The Author(s)


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