Chronic kidney disease and incident cancer risk: an individual participant data meta-analysis

CKD Prognosis Consortium; CKD-PC Data Coordinating Center; CKD-PC Steering Committee; ULSAM; UK Biobank; Taiwan MJ; SKS; SHARP; SEED; RCAV; Rancho Bernardo; PREVEND; OLDW; NYU; MESA; KCPS-II; Go-DARTS; Geisinger; GCKD; ESTHER; ELSA-Brasil; CRIC; CKD-REIN; CARE; BioVu; ARIC; ADVANCE; Yejin Mok; Aditya Surapaneni; Yingying Sang; Josef Coresh; Morgan Grams; Kunihiro Matsushita; Shoshana H. Ballew; Natalia Alencar de Pinho; Johan Ärnlöv; Sandhi M. Barreto; Samira Bell; Hermann Brenner; Juan Jesus Carrero; Rajkumar Chinnadurai; Elizabeth Ciemins; Ron T. Gansevoort; Simerjot K. Jassal; Keum Ji Jung; H. Lester Kirchner; Tsuneo Konta; Csaba P. Kovesdy; Li Luo; Krutika Pandit; Mahboob Rahman; Cassianne Robinson-Cohen; Charumathi Sabanayagam; Ulla T. Schultheiss; Michael G. Shlipak; Natalie Staplin; Marcello Tonelli; Angela Yee Moon Wang; Chi Pang Wen; Mark Woodward; Jennifer S. Lees

doi:10.1038/s41416-025-03140-z

Chronic kidney disease and incident cancer risk: an individual participant data meta-analysis

CKD Prognosis Consortium
, CKD-PC Data Coordinating Center
, CKD-PC Steering Committee
, ULSAM
, UK Biobank
, Taiwan MJ
, SKS
, SHARP
, SEED
, RCAV
, Rancho Bernardo
, PREVEND
, OLDW
, NYU
, MESA
, KCPS-II
, Go-DARTS
, Geisinger
, GCKD
, ESTHER

ELSA-Brasil, CRIC, CKD-REIN, CARE, BioVu, ARIC, ADVANCE, Yejin Mok, Aditya Surapaneni, Yingying Sang, Josef Coresh, Morgan Grams, Kunihiro Matsushita, Shoshana H. Ballew^*, Natalia Alencar de Pinho, Johan Ärnlöv, Sandhi M. Barreto, Samira Bell, Hermann Brenner, Juan Jesus Carrero, Rajkumar Chinnadurai, Elizabeth Ciemins, Ron T. Gansevoort, Simerjot K. Jassal, Keum Ji Jung, H. Lester Kirchner, Tsuneo Konta, Csaba P. Kovesdy, Li Luo, Krutika Pandit, Mahboob Rahman, Cassianne Robinson-Cohen, Charumathi Sabanayagam, Ulla T. Schultheiss, Michael G. Shlipak, Natalie Staplin, Marcello Tonelli, Angela Yee Moon Wang, Chi Pang Wen, Mark Woodward, Jennifer S. Lees

^*Corresponding author for this work

Cardiology

Johns Hopkins Bloomberg School of Public Health
New York University School of Medicine
University Paris-Sud
Karolinska Institutet
Dalarna University
Universidade Federal de Minas Gerais
University of Dundee School of Medicine
Ruprecht Karl University of Heidelberg
Stockholm County Council
Northern Care Alliance NHS Foundation Trust
American Medical Group Association
University Medical Centre Groningen
University of California at San Diego
Department of Veterans Affairs
Yonsei University
Geisinger Medical Center
Yamagata University
University of Tennessee Health Science Center
University Hospitals Case Medical Center
Vanderbilt University School of Medicine
Singapore National Eye Center
Duke-NUS Graduate Medical School
University of Freiburg
Synlab MVZ Humangenetik Freiburg GmbH
University of California at San Francisco
University of Oxford
Cumming School of Medicine
National University of Singapore
China Medical University Taichung
University of New South Wales
Imperial College London
University of Glasgow
NHS Greater Glasgow and Clyde
London School of Hygiene and Tropical Medicine
Tufts Medical Center
Uppsala University

Research output: Contribution to journal › Article › Academic › peer-review

5 Citations (Scopus)

3 Downloads (Pure)

Abstract

Background:

Studies examining the association of chronic kidney disease (CKD) with cancer risk have demonstrated conflicting results.

Methods:

This was an individual participant data meta-analysis including 54 international cohorts contributing to the CKD Prognosis Consortium. Included cohorts had data on albuminuria [urine albumin-to-creatinine ratio (ACR)], estimated glomerular filtration rate (eGFR), overall and site-specific cancer incidence, and established risk factors for cancer. Included participants were aged 18 years or older, without previous cancer or kidney failure.

Results:

Among 1,319,308 individuals, the incidence rate of overall cancer was 17.3 per 1000 person-years. Higher ACR was positively associated with cancer risk [adjusted hazard ratio 1.08 (95% CI 1.06–1.10) per 8-fold increase in ACR]. No association of eGFR with overall cancer risk was seen. For site-specific cancers, lower eGFR was associated with urological cancer and multiple myeloma, whereas higher ACR was associated with many cancer types (kidney, head/neck, colorectal, liver, pancreas, bile duct, stomach, larynx, lung, hemolymphatic, leukaemia, and multiple myeloma). Results were similar in a 1-year landmark analysis.

Discussion:

Albuminuria, but not necessarily eGFR, was independently associated with the subsequent risk of cancer. Our results warrant an investigation into mechanisms that explain the link between albuminuria and cancer.

Original language	English
Pages (from-to)	1535-1543
Number of pages	9
Journal	British Journal of Cancer
Volume	133
Issue number	10
DOIs	https://doi.org/10.1038/s41416-025-03140-z
Publication status	Published - 30 Nov 2025

Bibliographical note

Publisher Copyright:
© The Author(s) 2025.

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

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Chronic kidney disease and incident cancer riskFinal published version, 968 KBLicence: CC BY

Cite this

CKD Prognosis Consortium, CKD-PC Data Coordinating Center, CKD-PC Steering Committee, ULSAM, UK Biobank, Taiwan MJ, SKS, SHARP, SEED, RCAV, Rancho Bernardo, PREVEND, OLDW, NYU, MESA, KCPS-II, Go-DARTS, Geisinger, GCKD, ... Lees, J. S. (2025). Chronic kidney disease and incident cancer risk: an individual participant data meta-analysis. British Journal of Cancer, 133(10), 1535-1543. https://doi.org/10.1038/s41416-025-03140-z

@article{321ded7f61814d59ab6e6ce85a0f9b7e,

title = "Chronic kidney disease and incident cancer risk: an individual participant data meta-analysis",

abstract = "Background: Studies examining the association of chronic kidney disease (CKD) with cancer risk have demonstrated conflicting results. Methods: This was an individual participant data meta-analysis including 54 international cohorts contributing to the CKD Prognosis Consortium. Included cohorts had data on albuminuria [urine albumin-to-creatinine ratio (ACR)], estimated glomerular filtration rate (eGFR), overall and site-specific cancer incidence, and established risk factors for cancer. Included participants were aged 18 years or older, without previous cancer or kidney failure.Results:Among 1,319,308 individuals, the incidence rate of overall cancer was 17.3 per 1000 person-years. Higher ACR was positively associated with cancer risk [adjusted hazard ratio 1.08 (95\% CI 1.06–1.10) per 8-fold increase in ACR]. No association of eGFR with overall cancer risk was seen. For site-specific cancers, lower eGFR was associated with urological cancer and multiple myeloma, whereas higher ACR was associated with many cancer types (kidney, head/neck, colorectal, liver, pancreas, bile duct, stomach, larynx, lung, hemolymphatic, leukaemia, and multiple myeloma). Results were similar in a 1-year landmark analysis. Discussion: Albuminuria, but not necessarily eGFR, was independently associated with the subsequent risk of cancer. Our results warrant an investigation into mechanisms that explain the link between albuminuria and cancer.",

author = "\{CKD Prognosis Consortium\} and \{CKD-PC Data Coordinating Center\} and \{CKD-PC Steering Committee\} and ULSAM and \{UK Biobank\} and \{Taiwan MJ\} and SKS and SHARP and SEED and RCAV and \{Rancho Bernardo\} and PREVEND and OLDW and NYU and MESA and KCPS-II and Go-DARTS and Geisinger and GCKD and ESTHER and ELSA-Brasil and CRIC and CKD-REIN and CARE and BioVu and ARIC and ADVANCE and Yejin Mok and Aditya Surapaneni and Yingying Sang and Josef Coresh and Morgan Grams and Kunihiro Matsushita and Ballew, \{Shoshana H.\} and \{Alencar de Pinho\}, Natalia and Johan {\"A}rnl{\"o}v and Barreto, \{Sandhi M.\} and Samira Bell and Hermann Brenner and Carrero, \{Juan Jesus\} and Rajkumar Chinnadurai and Elizabeth Ciemins and Gansevoort, \{Ron T.\} and Jassal, \{Simerjot K.\} and Jung, \{Keum Ji\} and Kirchner, \{H. Lester\} and Tsuneo Konta and Kovesdy, \{Csaba P.\} and Li Luo and Krutika Pandit and Mahboob Rahman and Cassianne Robinson-Cohen and Charumathi Sabanayagam and Schultheiss, \{Ulla T.\} and Shlipak, \{Michael G.\} and Natalie Staplin and Marcello Tonelli and Wang, \{Angela Yee Moon\} and Wen, \{Chi Pang\} and Mark Woodward and Lees, \{Jennifer S.\} and Shlipak, \{Michael G.\} and Dorothea Nitsch and Levey, \{Andrew S.\} and Vilmantas Giedraitis and Anders Larsson and Jennifer Lees and Tsai, \{Min Kung\} and James Ritchie and Smeeta Sinha and Darren Green and Philip Kalra and Colin Baigent and Landray, \{Martin J.\} and William Herrington and Pavitra Thyagarajan and \{de Boer\}, \{Rudolf A.\}",

note = "Publisher Copyright: {\textcopyright} The Author(s) 2025.",

year = "2025",

month = nov,

day = "30",

doi = "10.1038/s41416-025-03140-z",

language = "English",

volume = "133",

pages = "1535--1543",

journal = "British Journal of Cancer",

issn = "0007-0920",

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number = "10",

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CKD Prognosis Consortium, CKD-PC Data Coordinating Center, CKD-PC Steering Committee, ULSAM, UK Biobank, Taiwan MJ, SKS, SHARP, SEED, RCAV, Rancho Bernardo, PREVEND, OLDW, NYU, MESA, KCPS-II, Go-DARTS, Geisinger, GCKD, ESTHER, ELSA-Brasil, CRIC, CKD-REIN, CARE, BioVu, ARIC, ADVANCE, Mok, Y, Surapaneni, A, Sang, Y, Coresh, J, Grams, M, Matsushita, K, Ballew, SH, Alencar de Pinho, N, Ärnlöv, J, Barreto, SM, Bell, S, Brenner, H, Carrero, JJ, Chinnadurai, R, Ciemins, E, Gansevoort, RT, Jassal, SK, Jung, KJ, Kirchner, HL, Konta, T, Kovesdy, CP, Luo, L, Pandit, K, Rahman, M, Robinson-Cohen, C, Sabanayagam, C, Schultheiss, UT, Shlipak, MG, Staplin, N, Tonelli, M, Wang, AYM, Wen, CP, Woodward, M & Lees, JS 2025, 'Chronic kidney disease and incident cancer risk: an individual participant data meta-analysis', British Journal of Cancer, vol. 133, no. 10, pp. 1535-1543. https://doi.org/10.1038/s41416-025-03140-z

TY - JOUR

T1 - Chronic kidney disease and incident cancer risk

T2 - an individual participant data meta-analysis

AU - CKD Prognosis Consortium

AU - CKD-PC Data Coordinating Center

AU - CKD-PC Steering Committee

AU - ULSAM

AU - UK Biobank

AU - Taiwan MJ

AU - SKS

AU - SHARP

AU - SEED

AU - RCAV

AU - Rancho Bernardo

AU - PREVEND

AU - OLDW

AU - NYU

AU - MESA

AU - KCPS-II

AU - Go-DARTS

AU - Geisinger

AU - GCKD

AU - ESTHER

AU - ELSA-Brasil

AU - CRIC

AU - CKD-REIN

AU - CARE

AU - BioVu

AU - ARIC

AU - ADVANCE

AU - Mok, Yejin

AU - Surapaneni, Aditya

AU - Sang, Yingying

AU - Coresh, Josef

AU - Grams, Morgan

AU - Matsushita, Kunihiro

AU - Ballew, Shoshana H.

AU - Alencar de Pinho, Natalia

AU - Ärnlöv, Johan

AU - Barreto, Sandhi M.

AU - Bell, Samira

AU - Brenner, Hermann

AU - Carrero, Juan Jesus

AU - Chinnadurai, Rajkumar

AU - Ciemins, Elizabeth

AU - Gansevoort, Ron T.

AU - Jassal, Simerjot K.

AU - Jung, Keum Ji

AU - Kirchner, H. Lester

AU - Konta, Tsuneo

AU - Kovesdy, Csaba P.

AU - Luo, Li

AU - Pandit, Krutika

AU - Rahman, Mahboob

AU - Robinson-Cohen, Cassianne

AU - Sabanayagam, Charumathi

AU - Schultheiss, Ulla T.

AU - Shlipak, Michael G.

AU - Staplin, Natalie

AU - Tonelli, Marcello

AU - Wang, Angela Yee Moon

AU - Wen, Chi Pang

AU - Woodward, Mark

AU - Lees, Jennifer S.

AU - Shlipak, Michael G.

AU - Nitsch, Dorothea

AU - Levey, Andrew S.

AU - Giedraitis, Vilmantas

AU - Larsson, Anders

AU - Lees, Jennifer

AU - Tsai, Min Kung

AU - Ritchie, James

AU - Sinha, Smeeta

AU - Green, Darren

AU - Kalra, Philip

AU - Baigent, Colin

AU - Landray, Martin J.

AU - Herrington, William

AU - Thyagarajan, Pavitra

AU - de Boer, Rudolf A.

PY - 2025/11/30

Y1 - 2025/11/30

N2 - Background: Studies examining the association of chronic kidney disease (CKD) with cancer risk have demonstrated conflicting results. Methods: This was an individual participant data meta-analysis including 54 international cohorts contributing to the CKD Prognosis Consortium. Included cohorts had data on albuminuria [urine albumin-to-creatinine ratio (ACR)], estimated glomerular filtration rate (eGFR), overall and site-specific cancer incidence, and established risk factors for cancer. Included participants were aged 18 years or older, without previous cancer or kidney failure.Results:Among 1,319,308 individuals, the incidence rate of overall cancer was 17.3 per 1000 person-years. Higher ACR was positively associated with cancer risk [adjusted hazard ratio 1.08 (95% CI 1.06–1.10) per 8-fold increase in ACR]. No association of eGFR with overall cancer risk was seen. For site-specific cancers, lower eGFR was associated with urological cancer and multiple myeloma, whereas higher ACR was associated with many cancer types (kidney, head/neck, colorectal, liver, pancreas, bile duct, stomach, larynx, lung, hemolymphatic, leukaemia, and multiple myeloma). Results were similar in a 1-year landmark analysis. Discussion: Albuminuria, but not necessarily eGFR, was independently associated with the subsequent risk of cancer. Our results warrant an investigation into mechanisms that explain the link between albuminuria and cancer.

AB - Background: Studies examining the association of chronic kidney disease (CKD) with cancer risk have demonstrated conflicting results. Methods: This was an individual participant data meta-analysis including 54 international cohorts contributing to the CKD Prognosis Consortium. Included cohorts had data on albuminuria [urine albumin-to-creatinine ratio (ACR)], estimated glomerular filtration rate (eGFR), overall and site-specific cancer incidence, and established risk factors for cancer. Included participants were aged 18 years or older, without previous cancer or kidney failure.Results:Among 1,319,308 individuals, the incidence rate of overall cancer was 17.3 per 1000 person-years. Higher ACR was positively associated with cancer risk [adjusted hazard ratio 1.08 (95% CI 1.06–1.10) per 8-fold increase in ACR]. No association of eGFR with overall cancer risk was seen. For site-specific cancers, lower eGFR was associated with urological cancer and multiple myeloma, whereas higher ACR was associated with many cancer types (kidney, head/neck, colorectal, liver, pancreas, bile duct, stomach, larynx, lung, hemolymphatic, leukaemia, and multiple myeloma). Results were similar in a 1-year landmark analysis. Discussion: Albuminuria, but not necessarily eGFR, was independently associated with the subsequent risk of cancer. Our results warrant an investigation into mechanisms that explain the link between albuminuria and cancer.

UR - https://www.scopus.com/pages/publications/105021352805

U2 - 10.1038/s41416-025-03140-z

DO - 10.1038/s41416-025-03140-z

M3 - Article

C2 - 40914744

AN - SCOPUS:105021352805

SN - 0007-0920

VL - 133

SP - 1535

EP - 1543

JO - British Journal of Cancer

JF - British Journal of Cancer

IS - 10

ER -

Chronic kidney disease and incident cancer risk: an individual participant data meta-analysis

Abstract

Bibliographical note

UN SDGs

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