TY - JOUR
T1 - Cigarette smoking and progressive brain volume loss in schizophrenia
AU - Van Haren, N. E.M.
AU - Koolschijn, P. C.M.P.
AU - Cahn, W.
AU - Schnack, H. G.
AU - Hulshoff Pol, H. E.
AU - Kahn, R. S.
PY - 2010/7
Y1 - 2010/7
N2 - It is unknown whether the reported brain loss in schizophrenia can be attributed to the effects of tobacco smoking. 96 Patients (54 smokers/42 non-smokers) and 113 control subjects (35/78) were included in a 5-year longitudinal MRI study. Despite the higher prevalence of smoking behavior and the higher number of cigarettes consumed per day in the patients, cigarette smoking did not explain the excessive cerebral (gray matter) volume decreases in the patients. Moreover, smoking was not associated with brain volume change over time in the healthy subjects. However, extremely heavy smoking may contribute to excessive gray matter volume loss in schizophrenia.
AB - It is unknown whether the reported brain loss in schizophrenia can be attributed to the effects of tobacco smoking. 96 Patients (54 smokers/42 non-smokers) and 113 control subjects (35/78) were included in a 5-year longitudinal MRI study. Despite the higher prevalence of smoking behavior and the higher number of cigarettes consumed per day in the patients, cigarette smoking did not explain the excessive cerebral (gray matter) volume decreases in the patients. Moreover, smoking was not associated with brain volume change over time in the healthy subjects. However, extremely heavy smoking may contribute to excessive gray matter volume loss in schizophrenia.
UR - http://www.scopus.com/inward/record.url?scp=77953363035&partnerID=8YFLogxK
U2 - 10.1016/j.euroneuro.2010.02.009
DO - 10.1016/j.euroneuro.2010.02.009
M3 - Article
C2 - 20227855
AN - SCOPUS:77953363035
SN - 0924-977X
VL - 20
SP - 454
EP - 458
JO - European Neuropsychopharmacology
JF - European Neuropsychopharmacology
IS - 7
ER -