Cigarette smoking and progressive brain volume loss in schizophrenia

N. E.M. Van Haren; P. C.M.P. Koolschijn; W. Cahn; H. G. Schnack; H. E. Hulshoff Pol; R. S. Kahn

doi:10.1016/j.euroneuro.2010.02.009

Cigarette smoking and progressive brain volume loss in schizophrenia

N. E.M. Van Haren^*
, P. C.M.P. Koolschijn
, W. Cahn
, H. G. Schnack
, H. E. Hulshoff Pol
, R. S. Kahn

^*Corresponding author for this work

Brain Centre Rudolf Magnus
University Medical Centre Utrecht

Research output: Contribution to journal › Article › Academic › peer-review

24 Citations (Scopus)

Abstract

It is unknown whether the reported brain loss in schizophrenia can be attributed to the effects of tobacco smoking. 96 Patients (54 smokers/42 non-smokers) and 113 control subjects (35/78) were included in a 5-year longitudinal MRI study. Despite the higher prevalence of smoking behavior and the higher number of cigarettes consumed per day in the patients, cigarette smoking did not explain the excessive cerebral (gray matter) volume decreases in the patients. Moreover, smoking was not associated with brain volume change over time in the healthy subjects. However, extremely heavy smoking may contribute to excessive gray matter volume loss in schizophrenia.

Original language	English
Pages (from-to)	454-458
Number of pages	5
Journal	European Neuropsychopharmacology
Volume	20
Issue number	7
DOIs	https://doi.org/10.1016/j.euroneuro.2010.02.009
Publication status	Published - Jul 2010
Externally published	Yes

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SDG 3 Good Health and Well-being

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10.1016/j.euroneuro.2010.02.009

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title = "Cigarette smoking and progressive brain volume loss in schizophrenia",

abstract = "It is unknown whether the reported brain loss in schizophrenia can be attributed to the effects of tobacco smoking. 96 Patients (54 smokers/42 non-smokers) and 113 control subjects (35/78) were included in a 5-year longitudinal MRI study. Despite the higher prevalence of smoking behavior and the higher number of cigarettes consumed per day in the patients, cigarette smoking did not explain the excessive cerebral (gray matter) volume decreases in the patients. Moreover, smoking was not associated with brain volume change over time in the healthy subjects. However, extremely heavy smoking may contribute to excessive gray matter volume loss in schizophrenia.",

author = "\{Van Haren\}, \{N. E.M.\} and Koolschijn, \{P. C.M.P.\} and W. Cahn and Schnack, \{H. G.\} and \{Hulshoff Pol\}, \{H. E.\} and Kahn, \{R. S.\}",

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AU - Van Haren, N. E.M.

AU - Koolschijn, P. C.M.P.

AU - Cahn, W.

AU - Schnack, H. G.

AU - Hulshoff Pol, H. E.

AU - Kahn, R. S.

PY - 2010/7

Y1 - 2010/7

N2 - It is unknown whether the reported brain loss in schizophrenia can be attributed to the effects of tobacco smoking. 96 Patients (54 smokers/42 non-smokers) and 113 control subjects (35/78) were included in a 5-year longitudinal MRI study. Despite the higher prevalence of smoking behavior and the higher number of cigarettes consumed per day in the patients, cigarette smoking did not explain the excessive cerebral (gray matter) volume decreases in the patients. Moreover, smoking was not associated with brain volume change over time in the healthy subjects. However, extremely heavy smoking may contribute to excessive gray matter volume loss in schizophrenia.

AB - It is unknown whether the reported brain loss in schizophrenia can be attributed to the effects of tobacco smoking. 96 Patients (54 smokers/42 non-smokers) and 113 control subjects (35/78) were included in a 5-year longitudinal MRI study. Despite the higher prevalence of smoking behavior and the higher number of cigarettes consumed per day in the patients, cigarette smoking did not explain the excessive cerebral (gray matter) volume decreases in the patients. Moreover, smoking was not associated with brain volume change over time in the healthy subjects. However, extremely heavy smoking may contribute to excessive gray matter volume loss in schizophrenia.

UR - https://www.scopus.com/pages/publications/77953363035

U2 - 10.1016/j.euroneuro.2010.02.009

DO - 10.1016/j.euroneuro.2010.02.009

M3 - Article

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SN - 0924-977X

VL - 20

SP - 454

EP - 458

JO - European Neuropsychopharmacology

JF - European Neuropsychopharmacology

IS - 7

ER -

Cigarette smoking and progressive brain volume loss in schizophrenia

Abstract

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