Circadian Gene Variants and Susceptibility to Type 2 Diabetes: A Pilot Study

MA Kelly, SD Rees, MZI Hydrie, AS Shera, S Bellary, JP O'Hare, S Kumar, S Taheri, A Basit, AH Barnett

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49 Citations (Scopus)

Abstract

Background: Disruption of endogenous circadian rhythms has been shown to increase the risk of developing type 2 diabetes, suggesting that circadian genes might play a role in determining disease susceptibility. We present the results of a pilot study investigating the association between type 2 diabetes and selected single nucleotide polymorphisms (SNPs) in/near nine circadian genes. The variants were chosen based on their previously reported association with prostate cancer, a disease that has been suggested to have a genetic link with type 2 diabetes through a number of shared inherited risk determinants. Methodology/Principal Findings:The pilot study was performed using two genetically homogeneous Punjabi cohorts, one resident in the United Kingdom and one indigenous to Pakistan. Subjects with (N = 1732) and without (N = 1780) type 2 diabetes were genotyped for thirteen circadian variants using a competitive allele-specific polymerase chain reaction method. Associations between the SNPs and type 2 diabetes were investigated using logistic regression. The results were also combined with in silico Conclusions/significance: None of the selected circadian gene variants was associated with type 2 diabetes with study-wide significance after meta-analysis. The nominal association observed with the CRY2 SNP, however, complements previous findings and confirms a role for this locus in disease susceptibility.
Original languageUndefined/Unknown
JournalPLoS One (print)
Volume7
Issue number4
DOIs
Publication statusPublished - 2012
Externally publishedYes

Research programs

  • EMC COEUR-09
  • EMC NIHES-01-64-02

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