Circulating chemokines in relation to coronary plaque characteristics on radiofrequency intravascular ultrasound and cardiovascular outcome

Jin Ming Cheng, Rohit Oemrawsingh, Martijn Akkerhuis, Hector Garcia Garcia, Sanneke Boer, Linda Battes, Nermina Buljubasic, Mattie Lenzen, Peter de Jaegere, Robert Jan van Geuns, PWJC (Patrick) Serruys, Isabella Kardys, Eric Boersma

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5 Citations (Scopus)

Abstract

Objective: To investigate relations of several circulating chemokines with extent and phenotype of coronary atherosclerosis and with 1-year clinical outcome. Methods: Intravascular ultrasound virtual histology (IVUS-VH) imaging of a coronary artery was performed in 581 patients. Monocyte chemoattractant protein-1 (MCP-1), macrophage inflammatory protein-1 alpha (MIP-1 alpha), MIP-1 beta and regulated upon activation normal T cell expressed and secreted (RANTES) were measured in plasma. Results: Higher MCP-1, MIP-1 alpha and lower RANTES were associated with coronary plaque burden. Higher MCP-1, MIP-1 alpha and lower RANTES were associated with the presence of IVUS-VH-derived thin-cap fibroatheroma lesions. RANTES was associated with major adverse cardiac events. Conclusions: RANTES is a promising biomarker that is inversely associated with coronary plaque burden and vulnerability, as well as with death and acute coronary syndrome.
Original languageUndefined/Unknown
Pages (from-to)611-619
Number of pages9
JournalBiomarkers
Volume19
Issue number7
DOIs
Publication statusPublished - 2014

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