Clinical and imaging studies in clinically suspect Arthralgia, targeting the right patient population

Research output: Types of ThesisDoctoral ThesisInternal

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Abstract

Approximately 50% of patients with rheumatoid arthritis (RA) have autoantibodies,
such as anti-citrullinated peptide antibodies (ACPA) and/or rheumatoid factor (RF).
Due to extensive research it was found that autoantibodies can be detected years
before the development of clinically apparent arthritis and that the onset of RA is
preceded by a complex preclinical phase. The symptomatic arthralgia phase, without
clinical apparent arthritis – also known as clinical suspect arthralgia (CSA), is the
first opportunity to clinically recognize patients at risk for RA. Multiple studies in
arthralgia patients have demonstrated autoantibodies to be the most powerful
predictors for development of clinical arthritis, however the majority of arthralgia
patients are ACPA negative.

Original languageEnglish
Awarding Institution
  • Erasmus University Rotterdam
Supervisors/Advisors
  • van Mil, Annette, Supervisor
  • de Jong, Pascal, Co-supervisor
Award date27 Feb 2024
Publication statusPublished - 27 Feb 2024

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