Clinical and intravascular imaging outcomes at 1 and 2 years after implantation of absorb everolimus eluting bioresorbable vascular scaffolds in small vessels. Late lumen enlargement: does bioresorption matter with small vessel size? Insight from the ABSORB cohort B trial

Roberto Diletti, V Farooq, Chrysafios Girasis, Fatma Bektas, Yoshinobu Onuma, JH Heo, Bill Gkogkas, Robert Jan van Geuns, Evelyn Regar, B de Bruyne, D Dudek, L Thuesen, B Chevalier, D McClean, S Windecker, RJ Whitbourn, P Smits, J Koolen, I Meredith, XL LiK Miquel-Hebert, S Veldhof, Hector Garcia Garcia, JA Ormiston, PWJC (Patrick) Serruys

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Abstract

Background The long-term results after second generation everolimus eluting bioresorbable vascular scaffold (Absorb BVS) placement in small vessels are unknown. Therefore, we investigated the impact of vessel size on long-term outcomes, after Absorb BVS implantation. Methods In ABSORB Cohort B Trial, out of the total study population (101 patients), 45 patients were assigned to undergo 6-month and 2-year angiographic follow-up (Cohort B1) and 56 patients to have angiographic follow-up at 1-year (Cohort B2). The pre-reference vessel diameter (RVD) was <2.5 mm (small-vessel group) in 41 patients (41 lesions) and >= 2.5 mm (large-vessel group) in 60 patients (61 lesions). Outcomes were compared according to pre-RVD. Results At 2-year angiographic follow-up no differences in late lumen loss (0.29 +/- 0.16 mm vs 0.25 +/- 0.22 mm, p=0.4391), and in-segment binary restenosis (5.3% vs 5.3% p=1.0000) were demonstrated between groups. In the small-vessel group, intravascular ultrasound analysis showed a significant increase in vessel area (12.25 +/- 3.47 mm(2) vs 13.09 +/- 3.38 mm(2) p=0.0015), scaffold area (5.76 +/- 0.96 mm(2) vs 6.41 +/- 1.30 mm(2) p=0.0008) and lumen area (5.71 +/- 0.98 mm(2) vs 6.20 +/- 1.27 Conclusions Similar clinical and angiographic outcomes at 2-year follow-up were reported in small and large vessel groups. A significant late lumen enlargement and positive vessel remodelling were observed in small vessels.
Original languageUndefined/Unknown
Pages (from-to)98-105
Number of pages8
JournalHeart
Volume99
Issue number2
DOIs
Publication statusPublished - 2013

Research programs

  • EMC COEUR-09

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