Clinical and Pathological Findings in SARS-CoV-2 Disease Outbreaks in Farmed Mink (Neovison vison)

Robert Jan Molenaar; Sandra Vreman; Renate W. Hakze-van der Honing; Rob Zwart; Jan de Rond; Eefke Weesendorp; Lidwien A.M. Smit; Marion Koopmans; Ruth Bouwstra; Arjan Stegeman; Wim H.M. van der Poel

doi:10.1177/0300985820943535

Clinical and Pathological Findings in SARS-CoV-2 Disease Outbreaks in Farmed Mink (Neovison vison)

Robert Jan Molenaar^*, Sandra Vreman, Renate W. Hakze-van der Honing, Rob Zwart, Jan de Rond, Eefke Weesendorp, Lidwien A.M. Smit, Marion Koopmans, Ruth Bouwstra, Arjan Stegeman, Wim H.M. van der Poel

^*Corresponding author for this work

Virology

Research output: Contribution to journal › Article › Academic › peer-review

117 Citations (Scopus)

44 Downloads (Pure)

Abstract

SARS-CoV-2, the causative agent of COVID-19, caused respiratory disease outbreaks with increased mortality in 4 mink farms in the Netherlands. The most striking postmortem finding was an acute interstitial pneumonia, which was found in nearly all examined mink that died at the peak of the outbreaks. Acute alveolar damage was a consistent histopathological finding in mink that died with pneumonia. SARS-CoV-2 infections were confirmed by detection of viral RNA in throat swabs and by immunohistochemical detection of viral antigen in nasal conchae, trachea, and lung. Clinically, the outbreaks lasted for about 4 weeks but some animals were still polymerase chain reaction–positive for SARS-CoV-2 in throat swabs after clinical signs had disappeared. This is the first report of the clinical and pathological characteristics of SARS-CoV-2 outbreaks in mink farms.

Original language	English
Pages (from-to)	653-657
Number of pages	5
Journal	Veterinary Pathology
Volume	57
Issue number	5
Early online date	14 Jul 2020
DOIs	https://doi.org/10.1177/0300985820943535
Publication status	Published - 1 Sept 2020

Bibliographical note

Funding Information:
The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: This research was commissioned and funded by the Dutch Ministry of Agriculture, Nature and Food.

Publisher Copyright:
© The Author(s) 2020.

Access to Document

10.1177/0300985820943535Licence: CC BY

Clinical and Pathological Findings in SARS-CoV-2 Disease Outbreaks in Farmed MinkFinal published version, 937 KBLicence: CC BY

Cite this

@article{3d46df93865e4fee95f78ef2c7e2b1a5,

title = "Clinical and Pathological Findings in SARS-CoV-2 Disease Outbreaks in Farmed Mink (Neovison vison)",

abstract = "SARS-CoV-2, the causative agent of COVID-19, caused respiratory disease outbreaks with increased mortality in 4 mink farms in the Netherlands. The most striking postmortem finding was an acute interstitial pneumonia, which was found in nearly all examined mink that died at the peak of the outbreaks. Acute alveolar damage was a consistent histopathological finding in mink that died with pneumonia. SARS-CoV-2 infections were confirmed by detection of viral RNA in throat swabs and by immunohistochemical detection of viral antigen in nasal conchae, trachea, and lung. Clinically, the outbreaks lasted for about 4 weeks but some animals were still polymerase chain reaction–positive for SARS-CoV-2 in throat swabs after clinical signs had disappeared. This is the first report of the clinical and pathological characteristics of SARS-CoV-2 outbreaks in mink farms.",

author = "Molenaar, {Robert Jan} and Sandra Vreman and {Hakze-van der Honing}, {Renate W.} and Rob Zwart and {de Rond}, Jan and Eefke Weesendorp and Smit, {Lidwien A.M.} and Marion Koopmans and Ruth Bouwstra and Arjan Stegeman and {van der Poel}, {Wim H.M.}",

note = "Funding Information: The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: This research was commissioned and funded by the Dutch Ministry of Agriculture, Nature and Food. Publisher Copyright: {\textcopyright} The Author(s) 2020.",

year = "2020",

month = sep,

day = "1",

doi = "10.1177/0300985820943535",

language = "English",

volume = "57",

pages = "653--657",

journal = "Veterinary Pathology",

issn = "0300-9858",

publisher = "SAGE Publications Ltd",

number = "5",

}

TY - JOUR

T1 - Clinical and Pathological Findings in SARS-CoV-2 Disease Outbreaks in Farmed Mink (Neovison vison)

AU - Molenaar, Robert Jan

AU - Vreman, Sandra

AU - Hakze-van der Honing, Renate W.

AU - Zwart, Rob

AU - de Rond, Jan

AU - Weesendorp, Eefke

AU - Smit, Lidwien A.M.

AU - Koopmans, Marion

AU - Bouwstra, Ruth

AU - Stegeman, Arjan

AU - van der Poel, Wim H.M.

N1 - Funding Information: The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: This research was commissioned and funded by the Dutch Ministry of Agriculture, Nature and Food. Publisher Copyright: © The Author(s) 2020.

PY - 2020/9/1

Y1 - 2020/9/1

N2 - SARS-CoV-2, the causative agent of COVID-19, caused respiratory disease outbreaks with increased mortality in 4 mink farms in the Netherlands. The most striking postmortem finding was an acute interstitial pneumonia, which was found in nearly all examined mink that died at the peak of the outbreaks. Acute alveolar damage was a consistent histopathological finding in mink that died with pneumonia. SARS-CoV-2 infections were confirmed by detection of viral RNA in throat swabs and by immunohistochemical detection of viral antigen in nasal conchae, trachea, and lung. Clinically, the outbreaks lasted for about 4 weeks but some animals were still polymerase chain reaction–positive for SARS-CoV-2 in throat swabs after clinical signs had disappeared. This is the first report of the clinical and pathological characteristics of SARS-CoV-2 outbreaks in mink farms.

AB - SARS-CoV-2, the causative agent of COVID-19, caused respiratory disease outbreaks with increased mortality in 4 mink farms in the Netherlands. The most striking postmortem finding was an acute interstitial pneumonia, which was found in nearly all examined mink that died at the peak of the outbreaks. Acute alveolar damage was a consistent histopathological finding in mink that died with pneumonia. SARS-CoV-2 infections were confirmed by detection of viral RNA in throat swabs and by immunohistochemical detection of viral antigen in nasal conchae, trachea, and lung. Clinically, the outbreaks lasted for about 4 weeks but some animals were still polymerase chain reaction–positive for SARS-CoV-2 in throat swabs after clinical signs had disappeared. This is the first report of the clinical and pathological characteristics of SARS-CoV-2 outbreaks in mink farms.

UR - http://www.scopus.com/inward/record.url?scp=85087937563&partnerID=8YFLogxK

U2 - 10.1177/0300985820943535

DO - 10.1177/0300985820943535

M3 - Article

C2 - 32663073

AN - SCOPUS:85087937563

SN - 0300-9858

VL - 57

SP - 653

EP - 657

JO - Veterinary Pathology

JF - Veterinary Pathology

IS - 5

ER -

Clinical and Pathological Findings in SARS-CoV-2 Disease Outbreaks in Farmed Mink (Neovison vison)

Abstract

Bibliographical note

Access to Document

Other files and links

Fingerprint

Cite this